Featured Research

from universities, journals, and other organizations

Removal of a tiny RNA molecule can inhibit cancer growth, researchers discover

Date:
June 7, 2011
Source:
University of Louisville
Summary:
Removing a tiny RNA molecule in mice has been found to suppress carcinogenic tumor formation. Researchers discovered that the removal of a non-coding RNA molecule known as MicroRNA 21 suppressed the formation of skin tumors in mice. This molecule -- abbreviated as miR-21 -- was targeted for study because of its presence in human cancer formation.

Research from the University of Louisville report in the Proceedings of the National Academy of Sciences indicates the removal of a tiny RNA molecule in mice suppresses carcinogenic tumor formation.

Yong Li, Ph.D., associate professor of biochemistry and molecular biology, and his research team led by postdoctoral fellows Xiaodong Ma and Munish Kumar found that the removal of a non-coding RNA molecule known as MicroRNA 21 suppressed the formation of skin tumors in mice. This molecule -- abbreviated as miR-21 -- was targeted for study because of its presence in human cancer formation, Li said.

"In virtually all types of cancer, miR-21 is found to be present at elevated levels," Li said. "We believe it is essential to the growth of cancers."

Two groups of mice -- 18 with miR-21 removed and a control group of 23 with miR-21 intact -- were studied after skin tumors known as papillomas were induced with a heavy dose of a carcinogen. The group without miR-21 had just 1.5 tumors per mouse after 30 weeks as compared to 2.5 tumors per mouse in the control group. Moreover, one of the mice without miR-21 was tumor-free at the end of the study.

"Our work leads us to believe that miR-21 ablation (removal) increases the body's own tumor suppressing ability to hold back tumors," Li said. "The cancer research community is increasingly aware the importance of the surroundings around tumor cells. Our ongoing study of miR-21 involves looking at how this molecule contributes to tumor environment."

The study's funding indicates the serendipitous aspect of bench science, Li said, because it was not funded by a cancer research agency or organization but in part by the American Heart Association and the UofL Diabetes and Obesity Center.

"We began our work in 2008 with the hypothesis that miR-21 plays a role in cardiovascular disease and diabetes," he said. "However, our research and reports from other groups suggest it does not, although we are continuing our work in these areas.

"Funding basic research is important because you never know where science will take you. It is clear from our research that miR-21 is taking us a bit closer to understanding tumor formation."


Story Source:

The above story is based on materials provided by University of Louisville. Note: Materials may be edited for content and length.


Journal Reference:

  1. X. Ma, M. Kumar, S. N. Choudhury, L. E. Becker Buscaglia, J. R. Barker, K. Kanakamedala, M.-F. Liu, Y. Li. Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1103735108

Cite This Page:

University of Louisville. "Removal of a tiny RNA molecule can inhibit cancer growth, researchers discover." ScienceDaily. ScienceDaily, 7 June 2011. <www.sciencedaily.com/releases/2011/06/110606152202.htm>.
University of Louisville. (2011, June 7). Removal of a tiny RNA molecule can inhibit cancer growth, researchers discover. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2011/06/110606152202.htm
University of Louisville. "Removal of a tiny RNA molecule can inhibit cancer growth, researchers discover." ScienceDaily. www.sciencedaily.com/releases/2011/06/110606152202.htm (accessed September 15, 2014).

Share This



More Health & Medicine News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Contagious Respiratory Illness Continues to Spread Across U.S.

Contagious Respiratory Illness Continues to Spread Across U.S.

Reuters - US Online Video (Sep. 12, 2014) Hundreds of children in several states have been stricken by a serious respiratory illness that is spreading across the U.S. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Batters Sierra Leone Economy Too

Ebola Batters Sierra Leone Economy Too

Reuters - Business Video Online (Sep. 12, 2014) The World Health Organisation warns that local health workers in West Africa can't keep up with Ebola - and among those countries hardest hit by the outbreak, the economic damage is coming into focus, too. As David Pollard reports, Sierra Leone admits that growth in one of the poorest economies in the region is taking a beating. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins