Featured Research

from universities, journals, and other organizations

Nicotine triggered appetite suppression site identified in brain

Date:
June 9, 2011
Source:
NIH/National Institute on Drug Abuse
Summary:
A new study uncovers a brain mechanism that could be targeted for new medications designed to help people quit smoking without gaining weight.

A new study uncovers a brain mechanism that could be targeted for new medications designed to help people quit smoking without gaining weight. This research shows that a specific subclass of brain nicotinic receptor is involved in nicotine's ability to reduce food intake in rodents. Prior research shows that the average weight gain after smoking is less than 10 pounds, but fear of weight gain can discourage some people who would like to quit.

In the study, to be published in the June 10 issue of Science, researchers found that a nicotine-like drug, cytisine, specifically activated nicotinic receptors in the hypothalamus -- a brain center that controls feeding. This resulted in the activation of a circuit that reduced food intake and body fat in a mouse model. This effect was very specific, since a drug that prevented cytisine from binding to its hypothalamic receptors blocked the reduction in food intake.

Through the use of tobacco, nicotine is one of the most heavily used addictive drugs and the leading preventable cause of disease, disability, and death in the United States. According to the Centers for Disease Control and Prevention, cigarette smoking results in more than 440,000 preventable deaths each year -- about 1 in 5 U.S. deaths overall. Despite the well-documented health costs of smoking, many smokers report great difficulty quitting.

"These mouse models allow us to explore the mechanisms through which nicotine acts in the brain to reduce food intake," said Dr. Marina Picciotto, of Yale University, New Haven, Conn. and senior author for the article. "We found that nicotine reduced eating and body fat through receptors implicated in nicotine aversion and withdrawal rather than reward and reinforcement."

"These results indicate that medications that specifically target this pathway could alleviate nicotine withdrawal as well as reduce the risk of overeating during smoking cessation," said NIDA Director Dr. Nora D. Volkow. "Although more research is warranted, such a highly selective compound might be more effective than drugs that act on more than one type of nicotinic receptor."

This research was funded by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health.


Story Source:

The above story is based on materials provided by NIH/National Institute on Drug Abuse. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yann S. Mineur, Alfonso Abizaid, Yan Rao, Ramiro Salas, Ralph J. Dileone, Daniela Gόndisch, Sabrina Diano, Mariella De Biasi, Tamas L. Horvath, Xiao-Bing Gao, Marina R. Picciotto. Nicotine Decreases Food Intake Through Activation of POMC Neurons. Science, 10 June 2011: Vol. 332 no. 6035 pp. 1330-1332 DOI: 10.1126/science.1201889

Cite This Page:

NIH/National Institute on Drug Abuse. "Nicotine triggered appetite suppression site identified in brain." ScienceDaily. ScienceDaily, 9 June 2011. <www.sciencedaily.com/releases/2011/06/110609151535.htm>.
NIH/National Institute on Drug Abuse. (2011, June 9). Nicotine triggered appetite suppression site identified in brain. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/06/110609151535.htm
NIH/National Institute on Drug Abuse. "Nicotine triggered appetite suppression site identified in brain." ScienceDaily. www.sciencedaily.com/releases/2011/06/110609151535.htm (accessed July 31, 2014).

Share This




More Mind & Brain News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dieting At A Young Age Might Lead To Harmful Health Habits

Dieting At A Young Age Might Lead To Harmful Health Habits

Newsy (July 30, 2014) — Researchers say women who diet at a young age are at greater risk of developing harmful health habits, including eating disorders and alcohol abuse. Video provided by Newsy
Powered by NewsLook.com
It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) — If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) — Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) — A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins