Featured Research

from universities, journals, and other organizations

New evidence of the benefits of home dialysis for kidney patients

Date:
June 21, 2011
Source:
St. Michael's Hospital
Summary:
Researchers have found more evidence of the benefits of home dialysis for patients with kidney failure.

Researchers at St. Michael's Hospital have found more evidence of the benefits of home dialysis for patients with kidney failure.

Related Articles


Cells that help protect blood vessels work better in patients who undergo dialysis at home during the night than those who undergo standard daytime dialysis in a hospital, according to Dr. Darren Yuen, a nephrologist.

This is important for patients with kidney failure, which causes damage to the endothelial cells that line blood vessels and help control the flow of blood. While standard dialysis in hospital is helpful for treating kidney failure, many patients still develop blood vessel damage that can lead to problems with walking or even amputation.

Dr. Yuen studied the function of cells called early-outgrowth endothelial progenitor-like cells (EPLCs). These cells, found in bone marrow and in the blood, can protect damaged endothelial cells and promote the growth of new ones, leading to healthier blood vessels.

Dr. Yuen compared patients who receive home dialysis at night with patients receiving standard dialysis three times a week in hospital. He found that EPLCs from patients receiving home dialysis promoted new blood vessel growth better than EPLCs from patients on standard hospital dialysis.

The results of his research appear in the June issue of the Clinical Journal of the American Society of Nephrology.

In his study, done in collaboration with the University Health Network, Dr. Yuen injected EPLCs from people receiving hospital dialysis into rats with blood vessel damage. He found no added improvements in blood vessel growth or blood circulation.

But when he injected EPLCs from patients undergoing nighttime dialysis at home, the results were almost as good as if the cells had come from healthy people.

Since home dialysis lasts for six to eight hours a night, five to six times a week, the toxins and other waste products that build up in kidney failure are more effectively removed, he said. The greater removal of these toxins may be responsible for the better function of EPLCs from patients on home dialysis, he said.

Dr. Yuen said his study suggests that frequent nighttime dialysis might be better for some patients with blood vessel damage. Nocturnal home hemodialysis originated in Toronto in 1994 at the Wellesley Hospital, which later merged with St. Michael's. St. Michael's also offers conventional hospital dialysis as well as another form of home dialysis known as peritoneal dialysis, in which cleansing fluids are pumped into a patient's abdomen through a catheter tube and waste products are drained several times a day.

Previous research has found that in addition to the convenience, patients on nighttime home dialysis feel better and have more energy when compared with patients who undergo conventional hospital dialysis.


Story Source:

The above story is based on materials provided by St. Michael's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. A. Yuen, M. A. Kuliszewski, C. Liao, D. Rudenko, H. Leong-Poi, C. T. Chan. Nocturnal Hemodialysis Is Associated with Restoration of Early-Outgrowth Endothelial Progenitor-Like Cell Function. Clinical Journal of the American Society of Nephrology, 2011; DOI: 10.2215/CJN.10911210

Cite This Page:

St. Michael's Hospital. "New evidence of the benefits of home dialysis for kidney patients." ScienceDaily. ScienceDaily, 21 June 2011. <www.sciencedaily.com/releases/2011/06/110621093311.htm>.
St. Michael's Hospital. (2011, June 21). New evidence of the benefits of home dialysis for kidney patients. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/06/110621093311.htm
St. Michael's Hospital. "New evidence of the benefits of home dialysis for kidney patients." ScienceDaily. www.sciencedaily.com/releases/2011/06/110621093311.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins