Featured Research

from universities, journals, and other organizations

Common rheumatoid arthritis and psoriasis medications are associated with reduced diabetes risk

Date:
June 22, 2011
Source:
Brigham and Women's Hospital
Summary:
Researchers sought to determine whether commonly used disease-modifying antirheumatic drugs, which are directed against inflammation, might reduce the risk for developing diabetes in patients with RA or psoriasis. They found that among patients with RA or psoriasis, the risk for developing diabetes was lower for those patients who started TNF inhibitor or hydroxychloroquine.

Individuals with systemic inflammatory conditions, such as rheumatoid arthritis (RA) and psoriasis, experience a 1.5 to 2-fold increased rate of cardiovascular disease. Previous research suggests that inflammation and insulin resistance, linked with these conditions, likely accelerate the development of cardiovascular risk and diabetes. Researchers at Brigham and Women's Hospital (BWH) sought to determine whether commonly used disease-modifying antirheumatic drugs (DMARDs), which are directed against inflammation, might reduce the risk for developing diabetes in patients with RA or psoriasis. They found that among patients with RA or psoriasis, the risk for developing diabetes was lower for those patients who started TNF inhibitor or hydroxychloroquine.

Their findings are published in the June 22/29, 2011 issue of the Journal of the American Medical Association.

"While there may be other mechanisms at play in these medications aside from their effect on inflammation, we observed a reduced risk for diabetes in patients with RA or psoriasis who were treated with tumor necrosis factor (TNF) inhibitors or hydroxycholoriquine when compared with patients who began treatment on other non-biologic DMARDs," said Daniel Solomon, MD, MPH, lead author of the study and a researcher in the Division of Rheumatology and the Division of Pharmacoepidemiology at BWH.

Researchers evaluated data gathered from 13,905 patients with RA or psoriasis with 22,493 new instances of treatment initiation. The patients were categorized based on four categories of commonly used DMARD regimens: non-biologic DMARDs, TNF inhibitors, methotrexate and hydroxychloroquine. The researchers found 267 newly diagnosed cases of diabetes: 55 cases among 3,993 patients treated with non-biologic DMARDs; 80 cases among 4,623 patients treated with TNF inhibitors; 82 cases among 8,195 patients treated with methotrexate; and 50 cases among 5,682 patients treated with hydroxychloroquine. Researchers report that the rate of newly diagnosed diabetes was highest in individuals who were treated with nonbiologic DMARDs and lowest for TNF inhibitor users. Additionally, when adjusting for other risk factors for diabetes, researchers found a reduced relative risk of diabetes in patients treated with TNF inhibitors and hydroxychloroquine compared with other non-biologic DMARDs.

"Our study shows an association between these two DMARDS (TNF inhibitors and hydroxychloroquine) and reduced diabetes risk, but we cannot be sure that the association is causal -- that the medications are the cause of the reduced risk. Currently we are working on an NIH sponsored randomized clinical trial using hydroxychloroquine in RA patients to assess for its effects on glucose and insulin. If this and other randomized clinical trials show the same relationships, then physicians may want to consider assessing their patients not only for the management of their RA or psoriasis, but also for insulin resistance," Solomon said.


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. H. Solomon, E. Massarotti, R. Garg, J. Liu, C. Canning, S. Schneeweiss. Association Between Disease-Modifying Antirheumatic Drugs and Diabetes Risk in Patients With Rheumatoid Arthritis and Psoriasis. JAMA: The Journal of the American Medical Association, 2011; 305 (24): 2525 DOI: 10.1001/jama.2011.878

Cite This Page:

Brigham and Women's Hospital. "Common rheumatoid arthritis and psoriasis medications are associated with reduced diabetes risk." ScienceDaily. ScienceDaily, 22 June 2011. <www.sciencedaily.com/releases/2011/06/110621164723.htm>.
Brigham and Women's Hospital. (2011, June 22). Common rheumatoid arthritis and psoriasis medications are associated with reduced diabetes risk. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2011/06/110621164723.htm
Brigham and Women's Hospital. "Common rheumatoid arthritis and psoriasis medications are associated with reduced diabetes risk." ScienceDaily. www.sciencedaily.com/releases/2011/06/110621164723.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins