Featured Research

from universities, journals, and other organizations

Angioplasty may be feasible for liver transplantation candidates with heart disease

Date:
June 22, 2011
Source:
Wiley-Blackwell
Summary:
A small, retrospective study determined that percutaneous coronary intervention (PCI) was safe in patients with significant coronary artery disease (CAD) who were referred for liver transplantation. Larger studies are needed to determine the effectiveness of angioplasty in patients with end-stage liver disease (ESLD).

A small, retrospective study determined that percutaneous coronary intervention (PCI) was safe in patients with significant coronary artery disease (CAD) who were referred for liver transplantation. Larger studies are needed to determine the effectiveness of angioplasty in patients with end-stage liver disease (ESLD).

Details of the study are available in the July issue of Liver Transplantation, published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

Medical evidence states that ESLD is associated with increased cardiovascular risk and CAD has been reported in up to 28% of this patient population, with those 50 years of age having the highest prevalence. Further studies have found that despite medical management or surgical revascularization, the three-year mortality of patients with CAD who receive liver transplants is 26% to 50%. Moreover, heart bypass surgery prior to transplantation can exacerbate liver failure and increase mortality risk.

"Our research is the first to demonstrate the feasibility and safety of PCI in patients with ESLD and thrombocytopenia who are candidates for liver transplantation," said Babak Azarbal, MD, interventional cardiologist at Cedars-Sinai Medical Center and lead author. In the past, PCI with stenting had not been used in patients with ESLD due to increased bleeding complications from peri- and post-procedural regimens that reduce the possibility of blood clots. These required anticoagulation and anti-platelet therapies could increase risk in ESLD patients with low platelets (thrombocytopenia) and bleeding disorders (coagulopathy).

The current study included 16 patients with ESLD who had significant CAD, but were acceptable candidates for liver transplantation. Fifteen patients underwent PCI using bare-metal stents and one patient had balloon angioplasty alone. Successful PCI was achieved in 94% of patients, with a single case of suboptimal residual stenosis following stenting. All patients remained clinically stable at one month following the intervention, with 9 patients added to the waiting list for liver transplantation and 3 who received liver transplants.

This research found PCI to be a safe and feasible option for ESLD patients with significant heart disease. Given the small sample size and retrospective nature of this study, the authors caution that their results may not be representative of the broader population of patients with ESLD and CAD. "Further investigation is needed to determine whether PCI improves clinical outcomes in ESLD patients with significant heart disease who otherwise would not be candidates for liver transplantation," concluded Antoine Hage, MD, Director of Solid Organ Transplant Cardiology at Cedars-Sinai Heart Institute in Beverly Hills, California and co-author of the study.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Babak Azarbal, Paul Poommipanit, Boris Arbit, Antoine Hage, Jignesh Patel, Michelle Kittleson, Saibal Kar, Fady M. Kaldas, Ronald W. Busuttil. Feasibility and safety of percutaneous coronary intervention in patients with end-stage liver disease referred for liver transplantation. Liver Transplantation, 2011; DOI: 10.1002/lt.22301

Cite This Page:

Wiley-Blackwell. "Angioplasty may be feasible for liver transplantation candidates with heart disease." ScienceDaily. ScienceDaily, 22 June 2011. <www.sciencedaily.com/releases/2011/06/110622072755.htm>.
Wiley-Blackwell. (2011, June 22). Angioplasty may be feasible for liver transplantation candidates with heart disease. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2011/06/110622072755.htm
Wiley-Blackwell. "Angioplasty may be feasible for liver transplantation candidates with heart disease." ScienceDaily. www.sciencedaily.com/releases/2011/06/110622072755.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins