Featured Research

from universities, journals, and other organizations

Understanding the antiepileptic benefits of an Atkins-like diet

Date:
July 8, 2011
Source:
Journal of Clinical Investigation
Summary:
Some individuals with epilepsy fail to respond to treatment with conventional drugs but benefit from consuming a ketogenic diet -- a high-fat, low-carbohydrate diet similar to the more commonly known Atkins diet. Researchers have now identified in mice the molecular mechanism responsible for the antiepileptic effects of the ketogenic diet.

Some individuals with epilepsy fail to respond to treatment with conventional drugs but benefit from consuming a ketogenic diet -- a high-fat, low-carbohydrate diet similar to the more commonly known Atkins diet. A team of researchers, led by Detlev Boison, at the Legacy Research Institute, Portland, has now identified in mice the molecular mechanism responsible for the antiepileptic effects of the ketogenic diet.

The team found that a ketogenic diet reduces seizures in mice by decreasing expression of the protein Adk, which is responsible for clearing the natural antiepileptic agent adenosine from the brain. The clinical relevance of these data are highlighted by the team's finding that brain tissue from patients with epilepsy that fails to respond to treatment with conventional drugs shows increased levels of Adk.

The team suggests that their data could lead to the development of less-restrictive antiepileptic diets and alternate pharmaceutical approaches to treatment, notions with which Robert Greene, at The University of Texas Southwestern Medical Center, Dallas, concurs in an accompanying commentary.

The research is published in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Susan A. Masino, Tianfu Li, Panos Theofilas, Ursula S. Sandau, David N. Ruskin, Bertil B. Fredholm, Jonathan D. Geiger, Eleonora Aronica, Detlev Boison. A ketogenic diet suppresses seizures in mice through adenosine A1 receptors. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI57813
  2. Robert W. Greene. Adenosine: front and center in linking nutrition and metabolism to neuronal activity. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI58391

Cite This Page:

Journal of Clinical Investigation. "Understanding the antiepileptic benefits of an Atkins-like diet." ScienceDaily. ScienceDaily, 8 July 2011. <www.sciencedaily.com/releases/2011/06/110623130144.htm>.
Journal of Clinical Investigation. (2011, July 8). Understanding the antiepileptic benefits of an Atkins-like diet. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/06/110623130144.htm
Journal of Clinical Investigation. "Understanding the antiepileptic benefits of an Atkins-like diet." ScienceDaily. www.sciencedaily.com/releases/2011/06/110623130144.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins