Featured Research

from universities, journals, and other organizations

Novel drug target for treatment of infection in bone

Date:
June 28, 2011
Source:
Royal College of Surgeons in Ireland (RCSI)
Summary:
New research has identified a novel drug target for the treatment of infection in bone. Bone disease or osteomyeltitis is a debilitating infectious disease of the bone which is associated with significant morbidity and mortality.

New research from the Royal College of Surgeons in Ireland (RCSI) has identified a novel drug target for the treatment of infection in bone. The research was recently published in the journal PLoS ONE* and won the Donegan Bronze Medal at the annual meeting of the Biomedical section of the Royal Academy of Medicine in Ireland.

Related Articles


Bone disease or Osteomyeltitis is a debilitating infectious disease of the bone which is associated with significant morbidity and mortality. It is characterised by severe inflammation and progressive bone destruction and is usually caused by the bacterium Staphylococcus aureus that lives commonly on human skin and in the nose. It can reach the bones through blood contamination, open wounds or during surgery and most often causes infections in people with compromised immune systems.

Dr. Steve Kerrigan, lead researcher said "Our findings identify the exact mechanism through which Staphylococcus aureus binds to bone cells and triggers their destruction. It appears that Staphylococcus aureus can bind to bone cells and force them to undergo programmed cell death or apoptosis. When this occurs bone cells die and do not rejuvenate themselves. This leads to severe weakening of the bone, increasing the risk of multiple fractures in these patients. Deletion of specific protein on Staphylococcus aureus that binds to bone cells prevents the death signal, thus making it an ideal candidate as a novel drug target and prevents our over-reliance on antibiotics to treat this disease."

Current treatment guidelines consist of aggressive prolonged antibiotic therapy, possibly combined with surgery. Prolonged antibiotic use is often less than successful as 40% of patients relapse within 2 months of finishing clinically effective therapy. Furthermore, prolonged exposure to antibiotics leads to a greater risk of adding to the global problem of multiple antibiotic resistant strains of bacteria.

Bone disease, or osteomyelitis, affects 1 in 5,000 people around the world. It can occur at any stage in life and attack any bone in the body, where it leads to progressive bone destruction.

The research is a result of a successful collaborative project carried out between the Host Infection Group led by Dr. Steve Kerrigan in the School of Pharmacy and Molecular and Cellular Therapeutics and the Tissue Engineering Research Group led by Prof Fergal O'Brien in the Department of Anatomy. This research was funded by the Science Foundation of Ireland Research Frontiers Programme.


Story Source:

The above story is based on materials provided by Royal College of Surgeons in Ireland (RCSI). Note: Materials may be edited for content and length.


Journal Reference:

  1. Tania Claro, Amro Widaa, Maghnus O'Seaghdha, Helen Miajlovic, Timothy J. Foster, Fergal J. O'Brien, Steven W. Kerrigan. Staphylococcus aureus Protein A Binds to Osteoblasts and Triggers Signals That Weaken Bone in Osteomyelitis. PLoS ONE, 2011; 6 (4): e18748 DOI: 10.1371/journal.pone.0018748

Cite This Page:

Royal College of Surgeons in Ireland (RCSI). "Novel drug target for treatment of infection in bone." ScienceDaily. ScienceDaily, 28 June 2011. <www.sciencedaily.com/releases/2011/06/110628095039.htm>.
Royal College of Surgeons in Ireland (RCSI). (2011, June 28). Novel drug target for treatment of infection in bone. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2011/06/110628095039.htm
Royal College of Surgeons in Ireland (RCSI). "Novel drug target for treatment of infection in bone." ScienceDaily. www.sciencedaily.com/releases/2011/06/110628095039.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins