Featured Research

from universities, journals, and other organizations

Factors affecting obstetric outcomes of IVF singletons

Date:
July 5, 2011
Source:
European Society of Human Reproduction and Embryology
Summary:
Researchers have further evidence of how maternal characteristics can influence the development of children born after in vitro fertilization. A study of all 8941 IVF children born in Sweden between 2002 and 2006 where only one baby was born as a result of a single pregnancy showed that maternal age, primiparity, smoking, maternal infertility and body mass index, both over and underweight, were associated with an adverse perinatal outcome.

In Sweden almost 40 000 children have now been born after IVF, around 3 500 each year, and IVF children constitute 3% of all newborns. "This represents a large number of children and any adverse outcomes related to IVF are therefore a major public health issue," said Dr. Antonina Sazonova, from Sahlgrenska University Hospital, Gothenburg, Sweden, who carried out the research with colleagues from the hospital and from Lund University. "New methods and more advanced techniques are being developed all the time, and safety and quality aspects have, rightly, been of great interest during the past few years. We particularly wanted to know whether the number of embryos transferred influenced obstetric outcomes."

Since 2004, 70% of all of Sweden's 13 000 per year IVF cycles have been single embryo transfer (SET). The policy of using SET has resulted in an unchanged live birth rate and a decrease in the multiple birth rate from 25% to 5%. Earlier research from the same group had shown that IVF singletons as a group, irrespective of the number of embryos transferred, had a poorer obstetric outcome than singletons in the general population. The researchers therefore decided to investigate predictors for an adverse outcome in singletons from IVF/ICSI.

"Besides the known predictors of particular maternal characteristics, we also included details of IVF techniques such as the number of oocytes retrieved, and differences in embryo culture and preservation. We wanted to find whether there was any independent association with the four outcomes -- preterm birth, small for gestational age, placenta previa, where the placenta grows in the lowest part of the uterus and covers the cervix, and placental abruption, where the placental lining separates from the uterus," said Dr. Sazonova.

The researchers found that primiparity, maternal smoking, BMI and "vanishing twin" (where a fetus dies in the uterus and is reabsorbed by the mother or the other twin) were all associated with a risk of pre-term birth (before 32 weeks gestation). Maternal age, primiparity, smoking, BMI, and years of infertility were associated with an increased risk of small for gestational age (SGA), but no association with the number of embryos transferred was found. Maternal age and blastocyst transfer (using five or six day embryos) were associated with an increased risk of placenta previa, whereas primiparity was associated with a decreased risk. The only significant factor associated with placental abruption was smoking.

"The finding of a positive association between blastocyst transfer and placenta previa is new and has not been described before," said Dr. Sazonova. "At a time when blastocyst transfer is increasingly used as a way of improving the chances of pregnancy, it is important that we should investigate this further. We also intend to look at differences in obstetric outcomes between singletons born from frozen/thawed cycles and compare them with singletons from fresh cycles and in the general population."

A better outcome for singletons after SET would increase the pressure on all IVF centres worldwide to introduce SET as their primary IVF transfer strategy, the researchers say. Today SET is most often performed in Sweden and the other Nordic countries, The Netherlands and Belgium, while in the rest of the world two or three embryos are still being transferred in the majority of IVF cycles. "SET means less social and economic burden on parents and healthcare systems, fewer risks of maternal complications, and healthier children," said Dr. Sazonova. "We hope that our analysis, which is not only large in terms of the numbers studied but includes a complete national cohort of IVF singletons, will add to the weight of evidence in favour of this practice."


Story Source:

The above story is based on materials provided by European Society of Human Reproduction and Embryology. Note: Materials may be edited for content and length.


Cite This Page:

European Society of Human Reproduction and Embryology. "Factors affecting obstetric outcomes of IVF singletons." ScienceDaily. ScienceDaily, 5 July 2011. <www.sciencedaily.com/releases/2011/07/110705091504.htm>.
European Society of Human Reproduction and Embryology. (2011, July 5). Factors affecting obstetric outcomes of IVF singletons. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2011/07/110705091504.htm
European Society of Human Reproduction and Embryology. "Factors affecting obstetric outcomes of IVF singletons." ScienceDaily. www.sciencedaily.com/releases/2011/07/110705091504.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins