Featured Research

from universities, journals, and other organizations

New microsystem for better drug-testing

Date:
July 6, 2011
Source:
University of Southampton
Summary:
Nanoscientists are working on a new microsystem for more efficient testing of pharmaceutical drugs to treat diseases such as cystic fibrosis, MG (myasthenia gravis) and epilepsy.

A University of Southampton nanoscientist is working on a new microsystem for more efficient testing of pharmaceutical drugs to treat diseases such as cystic fibrosis, MG (myasthenia gravis) and epilepsy.

Dr Maurits de Planque of ECS-Electronics and Computer Science at the University will develop a new method to investigate the ion channels that underlie these serious disorders and that are used to test the effectiveness of new drugs.

"At the moment, commercial testing of new drugs is carried out using ion channels in living cell membranes. This is a slow and difficult process, not least because producing too many channels actually kills the cells," said Dr de Planque

The researchers therefore plan to produce these ion channels without using cells, which is possible with so-called cell-free expression mixtures, and to insert the channels in a very stable artificial cell membrane which should enable faster, less expensive drug testing.

"Researchers have experimented with cell-free mixtures before, but they found that this method was not economical due to the amount of expensive biochemicals required," said Dr de Planque. "Our proposal to develop a new platform, which uses a couple of microlitres instead of millilitres, will be a very cost-effective way of doing this, particularly when the produced channel is directly inserted in a membrane for drug testing."

Dr de Planque is conducting this research over a two-year period in collaboration with biological scientists at the University of Southampton. He is Principal Investigator for the project: Microsystems for Coupled Expression and Electrophysiology of Ion Channels, which has been awarded a grant of 125,000 from the Engineering and Physical Sciences Research Council (EPSRC).


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Cite This Page:

University of Southampton. "New microsystem for better drug-testing." ScienceDaily. ScienceDaily, 6 July 2011. <www.sciencedaily.com/releases/2011/07/110706094333.htm>.
University of Southampton. (2011, July 6). New microsystem for better drug-testing. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2011/07/110706094333.htm
University of Southampton. "New microsystem for better drug-testing." ScienceDaily. www.sciencedaily.com/releases/2011/07/110706094333.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins