Featured Research

from universities, journals, and other organizations

How maternal smoking or nicotine use increases the risk of cardiovascular disease in later life

Date:
July 25, 2011
Source:
Wiley-Blackwell
Summary:
Scientists now understand more about why being exposed to nicotine while you were a fetus will increase your risk of developing cardiovascular disease as an adult.

Scientists now understand more about why being exposed to nicotine while you were a fetus will increase your risk of developing cardiovascular disease as an adult. "We have found distinct links between cigarette smoking or even using nicotine patches or gum and the long-term harm for the child," says Dr. DaLiao Xiao, a scientist who works at the Loma Linda University School of Medicine in California.

Related Articles


Publishing their research in the British Journal of Pharmacology, Xiao and colleagues showed that when he gave nicotine to pregnant rats, the offspring had higher risks of high blood pressure than animals whose mothers didn't receive nicotine during pregnancy. While the work was carried out in rats, these findings fitted well with studies carried out in people.

Importantly, the researchers have discovered that specific changes in the blood vessel walls account for this outcome. The study shows that nicotine causes the formation of chemicals, known as reactive oxygen species (ROS), in the walls of blood vessels in the fetus. These ROS cause permanent changes that alter the normal behaviour of the blood vessel. This faulty programming is then carried throughout the individual's life and may lead to high blood pressure in adults.

"Other researchers have shown that cigarette smoking or nicotine use in pregnant women results in an increased risk of hypertension and cardiovascular disease in adulthood. Our findings provide novel information of the fetal programming that links fetal nicotine exposure to the long term damage," says Xiao.

In a commentary accompanying the paper, Rebecca Lim, of The Ritchie Centre, Monash Institute of Medical Researc, and Associate Professor Christopher Sobey, of the Department of Pharmacology, Monash University, Australia, state: "If this is ultimately proven in humans, this important work will have revealed a novel cardiovascular risk factor that can only be modified before birth."


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal References:

  1. Daliao Xiao, Xiaohui Huang, Shumei Yang, Lubo Zhang. Antenatal Nicotine Induces Heightened Oxidative Stress and Vascular Dysfunction in Rat Offspring. British Journal of Pharmacology, 2011; DOI: 10.1111/j.1476-5381.2011.01437.x
  2. Rebecca Lim, Christopher G. Sobey. Maternal Nicotine Exposure and Fetal Programming of Vascular Oxidative Stress in Adult Offspring. British Journal of Pharmacology, 2011; DOI: 10.1111/j.1476-5381.2011.01488.x

Cite This Page:

Wiley-Blackwell. "How maternal smoking or nicotine use increases the risk of cardiovascular disease in later life." ScienceDaily. ScienceDaily, 25 July 2011. <www.sciencedaily.com/releases/2011/07/110720210654.htm>.
Wiley-Blackwell. (2011, July 25). How maternal smoking or nicotine use increases the risk of cardiovascular disease in later life. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2011/07/110720210654.htm
Wiley-Blackwell. "How maternal smoking or nicotine use increases the risk of cardiovascular disease in later life." ScienceDaily. www.sciencedaily.com/releases/2011/07/110720210654.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins