July 25, 2011 Scientists now understand more about why being exposed to nicotine while you were a fetus will increase your risk of developing cardiovascular disease as an adult. "We have found distinct links between cigarette smoking or even using nicotine patches or gum and the long-term harm for the child," says Dr. DaLiao Xiao, a scientist who works at the Loma Linda University School of Medicine in California.
Publishing their research in the British Journal of Pharmacology, Xiao and colleagues showed that when he gave nicotine to pregnant rats, the offspring had higher risks of high blood pressure than animals whose mothers didn't receive nicotine during pregnancy. While the work was carried out in rats, these findings fitted well with studies carried out in people.
Importantly, the researchers have discovered that specific changes in the blood vessel walls account for this outcome. The study shows that nicotine causes the formation of chemicals, known as reactive oxygen species (ROS), in the walls of blood vessels in the fetus. These ROS cause permanent changes that alter the normal behaviour of the blood vessel. This faulty programming is then carried throughout the individual's life and may lead to high blood pressure in adults.
"Other researchers have shown that cigarette smoking or nicotine use in pregnant women results in an increased risk of hypertension and cardiovascular disease in adulthood. Our findings provide novel information of the fetal programming that links fetal nicotine exposure to the long term damage," says Xiao.
In a commentary accompanying the paper, Rebecca Lim, of The Ritchie Centre, Monash Institute of Medical Researc, and Associate Professor Christopher Sobey, of the Department of Pharmacology, Monash University, Australia, state: "If this is ultimately proven in humans, this important work will have revealed a novel cardiovascular risk factor that can only be modified before birth."
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- Daliao Xiao, Xiaohui Huang, Shumei Yang, Lubo Zhang. Antenatal Nicotine Induces Heightened Oxidative Stress and Vascular Dysfunction in Rat Offspring. British Journal of Pharmacology, 2011; DOI: 10.1111/j.1476-5381.2011.01437.x
- Rebecca Lim, Christopher G. Sobey. Maternal Nicotine Exposure and Fetal Programming of Vascular Oxidative Stress in Adult Offspring. British Journal of Pharmacology, 2011; DOI: 10.1111/j.1476-5381.2011.01488.x
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