Featured Research

from universities, journals, and other organizations

Liver, belly fat may identify high risks of heart disease in obese people

Date:
July 22, 2011
Source:
American Heart Association
Summary:
Increased liver fat and abdominal fat may increase risk of heart disease and other serious health problems, according to researchers. Measuring liver and belly fat may identify obese people at risk of developing abnormal cholesterol. For some obese people, fat is not metabolically detrimental.

Obese people with high levels of abdominal fat and liver fat may face increased risks for heart disease and other serious health problems, according to research published in Arteriosclerosis, Thrombosis and Vascular Biology: Journal of the American Heart Association.

Obesity is commonly associated with heart disease risk and problems called cardiometabolic abnormalities, including insulin resistance, type 2 diabetes, cholesterol disorders, hypertension and gout.

Researchers in Sweden and Finland found that obese people at the highest risk have increased secretion of liver lipids, more abdominal fat and impaired removal of triglycerides from the blood stream. As such, doctors should routinely check obese patients for intra-abdominal obesity and indications of liver fat, researchers said.

"It is important to recognize that measuring abdominal fat and liver fat can identify the patients at high risk for metabolic abnormalities and heart disease," said Jan Boren, M.D., Ph.D., study senior author and professor of molecular and clinical medicine at the University of Gothenburg in Sweden. "Such exams are important because up to 20 percent of the obese appear to be "metabolically normal."

The researchers investigated what makes some obese people develop lipid disorders. They found that liver fat is strongly associated with increased secretion of very-low-density lipoproteins (VLDL), which contain the highest amount of triglycerides. High levels of triglycerides carry an increased risk of metabolic abnormalities and increased risk of heart disease and premature death.

"Increased liver fat is dangerous, as it is linked with many known heart disease risk factors," said Marja-Riitta Taskinen, M.D., Ph.D. study co-author and professor of medicine at the University of Helsinki in Finland. "Lifestyle modifications such as exercise and weight loss can reduce liver fat and the secretion of lipoproteins."

In the study, middle-aged Caucasian Finnish men were divided into three groups: 14 obese men had high triglycerides; 14 obese men had normal triglycerides and 10 men who were not obese and had normal triglycerides served as controls. The obese men's average age was 52 to 55 years. The non-obese men's average age was 48 years.

Researchers used proton magnetic resonance spectroscopy to measure liver fat, while subcutaneous abdominal and visceral fat were measured by magnetic resonance imaging.

The results showed that triglyceride levels in the obese men were higher as a result of the increased secretion coupled with severely impaired clearance of triglyceride-rich VLDL particles. Researchers also found:

  • The obese men with elevated triglycerides had a liver fat content of 13 percent.
  • The obese men with normal triglycerides had a 6.9 percent liver fat content.
  • The non-obese men had a 2.9 percent liver fat content.

Researchers plan to conduct a similar study in women.

Other co-authors are: Martin Adiels, Ph.D.; Jukka Westerbacka, M.D., Ph.D.; Sanni Soderllund, M.D.; Juhani Kahri, M.D., Ph.D.; Nina Lundbom, M.D., Ph.D.; Jesper Lundbom, M.S.; Antti Hakkaarain, B.S.; Swen-Olof Olofsson, M.D., Ph.D. and Marja Ortho-Melander, Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marja-Riitta Taskinen, Martin Adiels, Jukka Westerbacka, Sanni Sφderlund, Juhani Kahri, Nina Lundbom, Jesper Lundbom, Antti Hakkarainen, Sven-Olof Olofsson, Marju Orho-Melander, Jan Borιn. Dual Metabolic Defects Are Required to Produce Hypertriglyceridemia in Obese Subjects. Arteriosclerosis, Thrombosis and Vascular Biology, 2011; DOI: 10.1161/ATVBAHA.111.224808

Cite This Page:

American Heart Association. "Liver, belly fat may identify high risks of heart disease in obese people." ScienceDaily. ScienceDaily, 22 July 2011. <www.sciencedaily.com/releases/2011/07/110721163021.htm>.
American Heart Association. (2011, July 22). Liver, belly fat may identify high risks of heart disease in obese people. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2011/07/110721163021.htm
American Heart Association. "Liver, belly fat may identify high risks of heart disease in obese people." ScienceDaily. www.sciencedaily.com/releases/2011/07/110721163021.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) — Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) — Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) — Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins