Featured Research

from universities, journals, and other organizations

A heart-rate-reducing medication reduces the risk of heart failure and cardiac fibrosis

Date:
July 28, 2011
Source:
Montreal Heart Institute
Summary:
A new study suggest that ivabradine, a heart rate reduction medication, is also effective in reducing the risk of diastolic heart failure (left ventricular insufficiency) and cardiac fibrosis.

The findings of a Montreal Heart Institute (MHI) study published in the scientific journal Cardiology suggest that ivabradine, a heart rate reduction medication, is also effective in reducing the risk of diastolic heart failure (left ventricular insufficiency) and cardiac fibrosis.

The benefits of slower heart rate on mortality and morbidity associated with cardiovascular disease no longer need to be demonstrated. In this study, researchers sought to determine the effectiveness of ivabradine in treating diastolic dysfunction of the left ventricle, a condition affecting 40% of people with heart failure.

The study was conducted on rabbits given a standard diet, a cholesterol-enriched diet or a cholesterol-enriched diet with ivabradine. It revealed that as well as improving the myocardial performance index, ivabradine greatly improved left ventricular diastolic dysfunction in animals receiving a cholesterol-enriched diet. Ivabradine also reduced fibrosis of the heart chambers.

According to Dr. Jean-Claude Tardif, Director of the MHI Research Centre and professor of medicine at the Université de Montréal, the results are both interesting and encouraging. "The effectiveness of ivabradine in treating angina pectoris is now well known. However, few treatments are available to patients with diastolic heart failure. The beneficial effects of ivabradine demonstrated in laboratory suggest that this course of treatment should be further investigated." Clinical studies with subjects are expected to follow.


Story Source:

The above story is based on materials provided by Montreal Heart Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. David Busseuil, Yanfen Shi, Mélanie Mecteau, Geneviève Brand, Marc-Antoine Gillis, Eric Thorin, Caroline Asselin, Philippe Roméo, Tack Ki Leung, Jean-Gilles Latour, Christine Des Rosiers, Muriel Bouly, Eric Rhéaume, Jean-Claude Tardif. Heart Rate Reduction by Ivabradine Reduces Diastolic Dysfunction and Cardiac Fibrosis. Cardiology, 2010; 117 (3): 234 DOI: 10.1159/000322905

Cite This Page:

Montreal Heart Institute. "A heart-rate-reducing medication reduces the risk of heart failure and cardiac fibrosis." ScienceDaily. ScienceDaily, 28 July 2011. <www.sciencedaily.com/releases/2011/07/110728103136.htm>.
Montreal Heart Institute. (2011, July 28). A heart-rate-reducing medication reduces the risk of heart failure and cardiac fibrosis. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2011/07/110728103136.htm
Montreal Heart Institute. "A heart-rate-reducing medication reduces the risk of heart failure and cardiac fibrosis." ScienceDaily. www.sciencedaily.com/releases/2011/07/110728103136.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) — California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) — The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins