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A heart-rate-reducing medication reduces the risk of heart failure and cardiac fibrosis

Date:
July 28, 2011
Source:
Montreal Heart Institute
Summary:
A new study suggest that ivabradine, a heart rate reduction medication, is also effective in reducing the risk of diastolic heart failure (left ventricular insufficiency) and cardiac fibrosis.

The findings of a Montreal Heart Institute (MHI) study published in the scientific journal Cardiology suggest that ivabradine, a heart rate reduction medication, is also effective in reducing the risk of diastolic heart failure (left ventricular insufficiency) and cardiac fibrosis.

The benefits of slower heart rate on mortality and morbidity associated with cardiovascular disease no longer need to be demonstrated. In this study, researchers sought to determine the effectiveness of ivabradine in treating diastolic dysfunction of the left ventricle, a condition affecting 40% of people with heart failure.

The study was conducted on rabbits given a standard diet, a cholesterol-enriched diet or a cholesterol-enriched diet with ivabradine. It revealed that as well as improving the myocardial performance index, ivabradine greatly improved left ventricular diastolic dysfunction in animals receiving a cholesterol-enriched diet. Ivabradine also reduced fibrosis of the heart chambers.

According to Dr. Jean-Claude Tardif, Director of the MHI Research Centre and professor of medicine at the Université de Montréal, the results are both interesting and encouraging. "The effectiveness of ivabradine in treating angina pectoris is now well known. However, few treatments are available to patients with diastolic heart failure. The beneficial effects of ivabradine demonstrated in laboratory suggest that this course of treatment should be further investigated." Clinical studies with subjects are expected to follow.


Story Source:

The above story is based on materials provided by Montreal Heart Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. David Busseuil, Yanfen Shi, Mélanie Mecteau, Geneviève Brand, Marc-Antoine Gillis, Eric Thorin, Caroline Asselin, Philippe Roméo, Tack Ki Leung, Jean-Gilles Latour, Christine Des Rosiers, Muriel Bouly, Eric Rhéaume, Jean-Claude Tardif. Heart Rate Reduction by Ivabradine Reduces Diastolic Dysfunction and Cardiac Fibrosis. Cardiology, 2010; 117 (3): 234 DOI: 10.1159/000322905

Cite This Page:

Montreal Heart Institute. "A heart-rate-reducing medication reduces the risk of heart failure and cardiac fibrosis." ScienceDaily. ScienceDaily, 28 July 2011. <www.sciencedaily.com/releases/2011/07/110728103136.htm>.
Montreal Heart Institute. (2011, July 28). A heart-rate-reducing medication reduces the risk of heart failure and cardiac fibrosis. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2011/07/110728103136.htm
Montreal Heart Institute. "A heart-rate-reducing medication reduces the risk of heart failure and cardiac fibrosis." ScienceDaily. www.sciencedaily.com/releases/2011/07/110728103136.htm (accessed April 19, 2014).

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