Featured Research

from universities, journals, and other organizations

Male circumcision lowers prevalence of penile precancerous lesions among African men, study finds

Date:
July 28, 2011
Source:
University of North Carolina School of Medicine
Summary:
An international study shows that among Kenyan men, circumcision is associated with a lower prevalence of human papillomavirus-associated precancerous lesions of the penis.

A University of North Carolina-led international study shows that among Kenyan men, circumcision is associated with a lower prevalence of human papillomavirus-associated precancerous lesions of the penis. Human papillomavirus -- HPV -- is a sexually transmitted virus that plays an important role in genital cancers in men and women, including cancers of the penis and cervix.

Related Articles


Jennifer Smith, PhD, senior author, says, "Our data are the first to show that male circumcision may reduce HPV-associated penile precancerous lesions. This represents an additional public health benefit of male circumcision."

Smith is associate professor of epidemiology in the UNC Gillings School of Global Public Health and a member of UNC Lineberger Comprehensive Cancer Center.

The study was published as an online manuscript in May 2011 in the International Journal of Cancer.

Smith explains, "The percentage of men with HPV-associated precancerous penile lesions was substantially higher among those who were not circumcised -- 26 percent- compared to those who were circumcised -- .7 percent."

She adds, "Interventions that reduce HPV-associated penile lesions could be important to both men and women, because such lesions may increase HPV transmission from men to their sexual partners.

"Circumcision may also provide a useful intervention to prevent HPV-associated penile lesions and ultimately invasive cervical cancers in less developed countries, since prophylactic HPV vaccines may not be readily available to men, and current HPV vaccines do not include protection against all high-risk HPV types."

The study was part of a larger trial undertaken to determine the effectiveness of male circumcision in reducing HIV incidence conducted by Robert Bailey, PhD with the University of Illinois at Chicago. In the UNC-led study, 275 men participated: 151 who were circumcised and 124 who were not. The protocol included a visual inspection of the penis to identify lesions and photographs that were read independently by two observers as well as a sample of penile exfoliated cells that were tested for HPV infection.

Other UNC scientists are Danielle Backes, PhD, the report's first author and postdoctoral fellow, and Michael Hudgens, PhD. Other institutions are: Department of Pathology, Vrije Universiteit Medical Center in Amsterdam, and the Albert Schweitzer Hospital in Dordrecht, both in the Netherlands; the Nyzanza Reproductive Health Society, Kisumu, Kenya; the Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Illinois; the University of Nairobi, in Nairobi, Kenya; and the Centre for Global Public Health, University of Manitoba in Winnipeg, Canada.

Funding for the research was provided by grants from the National Cancer Institute and the Canadian Institute of Health Research.


Story Source:

The above story is based on materials provided by University of North Carolina School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Danielle M. Backes, Maaike C.G. Bleeker, Chris J.L.M. Meijer, Michael G. Hudgens, Kawango Agot, Robert C. Bailey, J.O. Ndinya-Achola, Juma Hayombe, Cornelis J.A. Hogewoning, Stephen Moses, Peter J.F. Snijders, Jennifer S. Smith. Male circumcision is associated with a lower prevalence of human papillomavirus-associated penile lesions among Kenyan men. International Journal of Cancer, 2011; DOI: 10.1002/ijc.26196

Cite This Page:

University of North Carolina School of Medicine. "Male circumcision lowers prevalence of penile precancerous lesions among African men, study finds." ScienceDaily. ScienceDaily, 28 July 2011. <www.sciencedaily.com/releases/2011/07/110728111545.htm>.
University of North Carolina School of Medicine. (2011, July 28). Male circumcision lowers prevalence of penile precancerous lesions among African men, study finds. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2011/07/110728111545.htm
University of North Carolina School of Medicine. "Male circumcision lowers prevalence of penile precancerous lesions among African men, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/07/110728111545.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins