Featured Research

from universities, journals, and other organizations

Out of body experience for stem cells may lead to more successful transplants

Date:
August 4, 2011
Source:
Cell Press
Summary:
New research finds that growing blood stem cells in the laboratory for about a week may help to overcome one of the most difficult roadblocks to successful transplantation, immune rejection. The study may lead to more promising therapeutic strategies for transplanting blood stem cells.

New research finds that growing blood stem cells in the laboratory for about a week may help to overcome one of the most difficult roadblocks to successful transplantation, immune rejection. The study, published by Cell Press in the August issue of the journal Cell Stem Cell, may lead to more promising therapeutic strategies for transplanting blood stem cells.

Hematopoietic stem cells (HSCs) are cells that can give rise to all of the different types of blood cells. Transplantation of HSCs has been used to treat leukemia, lymphoma, and other types of cancer, as well as some autoimmune diseases. However, there is a significant risk that the transplanted cells will fail to be incorporated into the host, or that the new cells will be rejected by the immune system and the patient will develop life-threatening "graft-versus-host" disease. Although scientists have identified some causes of transplant failure, many questions remain unanswered.

"The resolution of these questions will promote the understanding of the immunology of blood-forming stem cells and other stem cells and greatly improve the practice of transplantation," explains senior study author, Dr. Cheng Cheng Zhang from the University of Texas Southwestern Medical Center.

Dr. Zhang and colleagues had previously shown that they could successfully grow isolated mouse and human HSCs in the laboratory for transplantation and that there was a change in many of the proteins expressed on the surface of the cells. The researchers wondered whether this 'out of body experience' might change the functional properties of the cells as well and make them better suited for transplantation. They were specifically interested in clinically relevant "allogeneic" transplants, transplants between individuals who are genetically different, including siblings and unrelated donor/recipient pairs. Dr. Zhang's group transplanted freshly isolated HSCs or HSCs that were grown in the lab into mice and discovered that the HSCs that spent about a week growing in the lab were less likely to be rejected and more likely to be successfully incorporated into the recipient's blood.

The researchers went on to look at the mechanism that underlies this effect, and found that the lab-grown HSCs started to produce a specific immune system inhibitor on their surface that contributed to the improved transplantation efficiency.

"This work should shed new light on understanding the immunology of HSCs and other stem cells and may lead to development of novel strategies for successful allogeneic transplantation of human patients," concludes Dr. Zhang. "If donor human HSCs can be expanded in culture and engraft non-matched or low-matched patients without graft-versus-host disease, this strategy will possibly lead to an ultimate solution to problems in allogeneic transplantation."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Junke Zheng, Masato Umikawa, Shichuan Zhang, HoangDinh Huynh, Robert Silvany, Benjamin P.C. Chen, Lieping Chen, Cheng Cheng Zhang. Ex Vivo Expanded Hematopoietic Stem Cells Overcome the MHC Barrier in Allogeneic Transplantation. Cell Stem Cell, 2011; 9 (2): 119-130 DOI: 10.1016/j.stem.2011.06.003

Cite This Page:

Cell Press. "Out of body experience for stem cells may lead to more successful transplants." ScienceDaily. ScienceDaily, 4 August 2011. <www.sciencedaily.com/releases/2011/08/110804123859.htm>.
Cell Press. (2011, August 4). Out of body experience for stem cells may lead to more successful transplants. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2011/08/110804123859.htm
Cell Press. "Out of body experience for stem cells may lead to more successful transplants." ScienceDaily. www.sciencedaily.com/releases/2011/08/110804123859.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

More Coverage


Researchers Find Way to Help Donor Adult Blood Stem Cells Overcome Transplant Rejection

Aug. 4, 2011 Findings may suggest new strategies for successful donor adult stem cell transplants in patients with blood cancers such as leukemia, lymphoma and ... read more

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins