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Drug development in the blink of an eye

Date:
August 12, 2011
Source:
Journal of Clinical Investigation
Summary:
The development of drugs for brain-related conditions is not an efficient process. A key reason for this is a lack of preclinical tests that accurately predict drug efficacy and detect unwanted side effects. But now, researchers have developed a new preclinical approach that they hope can be used alongside current strategies to guide more efficient drug development for brain-related conditions.

The development of drugs for brain-related conditions is not an efficient process; only 8% of candidate drugs that enter clinical trials gain FDA approval. A key reason for this low success rate is a lack of preclinical tests that accurately predict drug efficacy and detect unwanted side effects.

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But now, Jeremy Nathans and colleagues, at Johns Hopkins University School of Medicine, Baltimore, have developed a new preclinical approach that they hope can be used alongside current strategies to guide more efficient drug development for brain-related conditions.

In the study, Nathans and colleagues show that a wide variety of psychoactive compounds -- sedatives; antipsychotic, antidepressant, and antiseizure drugs; and drugs of abuse, such as cocaine, morphine, and phencyclidine -- induce characteristic alterations in eye movements in mice and that monitoring these changes can be used to rapidly and quantitatively assess the response of mice to these compounds. An example of the utility of this approach was demonstrated by its use to monitor disease progression in a mouse model of the neurodegenerative condition Huntington disease; the results suggest that it could be used to assess the effectiveness of candidate Huntington disease therapeutics.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hugh Cahill, Amir Rattner, Jeremy Nathans. Preclinical assessment of CNS drug action using eye movements in mice. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI45557

Cite This Page:

Journal of Clinical Investigation. "Drug development in the blink of an eye." ScienceDaily. ScienceDaily, 12 August 2011. <www.sciencedaily.com/releases/2011/08/110808124234.htm>.
Journal of Clinical Investigation. (2011, August 12). Drug development in the blink of an eye. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2011/08/110808124234.htm
Journal of Clinical Investigation. "Drug development in the blink of an eye." ScienceDaily. www.sciencedaily.com/releases/2011/08/110808124234.htm (accessed October 30, 2014).

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