Featured Research

from universities, journals, and other organizations

Siblings of those with blood clots in leg have higher risk of same disorder

Date:
August 8, 2011
Source:
American Heart Association
Summary:
People with multiple siblings who had potentially life-threatening leg blood clots are 50 times more likely to get the same condition compared to people with healthy siblings. Hereditary factors -- as determined by sibling history -- are significant in determining the risk of venous thromboembolism in men and women between the ages of 10 and 69. VTE is the third most common cardiovascular illness after stroke and heart.

Siblings of those who have been hospitalized with potentially lethal blood clots in the legs or pelvis are more likely to also suffer the disorder than those with healthy siblings, according to research published in Circulation: Journal of the American Heart Association.

The Swedish study is the first to show a direct correlation between venous thromboembolism (VTE) and family risk in a nationwide setting, sorted by age and gender.

VTE consists of deep vein thrombosis (DVT), which typically involves blood clots that form in the deep veins of the leg or pelvis, and its complication, pulmonary embolism (PE), a blood clot that travels to the lungs and lodges within the pulmonary arteries.

"Hereditary factors -- as determined by sibling history -- are significant in determining the risk of venous thromboembolism in men and women between the ages of 10 and 69," said Bengt Zφller, M.D., Ph.D., senior study author and associate professor at the Center for Primary Health Care Research, Lund University in Malmφ, Sweden. "More importantly, in a fraction of the families we studied, the risk for venous thromboembolism was unusually high -- 50 to 60 times higher than those families who were not at risk, thus suggesting a strong genetic risk factor."

While the risk was two times greater for those with one sibling with VTE, the risk rose to 50 times greater for those with two or more siblings with the disorder.

Researchers compiled information from nationwide Swedish registries in 1987-2007, including the Hospital Discharge Register and the Swedish Multigeneration Register. They identified 45,362 hospitalized cases of VTE. Patients were ages 10 to 69 (48.5 percent male; 51.5 percent female), an average 50.7 years for men and 46.6 years for women. Of the total number of cases, 2,393 -- or 5.3 percent -- showed a sibling history for the disease.

Researchers also noted that:

  • For men and women 10-19 years old with a sibling history of the disease, the risk was almost five times greater than for those without a sibling history.
  • For those aged 60-69, the risk was twice as great for those with a sibling history.
  • Age differences among siblings had little impact on the disorder, which indicates there was no major familial environmental effect.
  • While sibling and non-sibling incidence rates increased exponentially for both sexes, overall it was higher for women than for men, especially between ages 10-40. However, after age 50, the incidence rate was higher for men.

In examining the risk for people with a spouse who had venous thromboembolism versus those with spouses who didn't, researchers found only a slight increased risk for venous thromboembolism. Thus, most of the familial risk may be due to genetics rather than family environmental factors, researchers said.

VTE is the third most common cardiovascular illness after stroke and heart attack, affecting one in 1,000 people each year, researchers said.

"Our study underscores the potential value of sibling history as a predictor of the risk of venous thromboembolism," Zφller said. "Further research is needed to uncover the sources of genetic and non-genetic occurrences of VTE.

Co-authors are: Xinjun Li, M.D., Ph.D.; Jan Sundquist, M.D., Ph.D.; and Kristina Sundquist, M.D., Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Siblings of those with blood clots in leg have higher risk of same disorder." ScienceDaily. ScienceDaily, 8 August 2011. <www.sciencedaily.com/releases/2011/08/110808161127.htm>.
American Heart Association. (2011, August 8). Siblings of those with blood clots in leg have higher risk of same disorder. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2011/08/110808161127.htm
American Heart Association. "Siblings of those with blood clots in leg have higher risk of same disorder." ScienceDaily. www.sciencedaily.com/releases/2011/08/110808161127.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) — A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) — A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) — Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) — The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins