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Exercise may help prevent brain damage caused by Alzheimer's disease

Date:
August 15, 2011
Source:
Elsevier
Summary:
Regular exercise could help prevent brain damage associated with neurodegenerative diseases like Alzheimer's, according to new research.

Regular exercise could help prevent brain damage associated with neurodegenerative diseases like Alzheimer's, according to research published this month in Elsevier's journal Brain, Behavior, and Immunity.

"Exercise allows the brain to rapidly produce chemicals that prevent damaging inflammation," said Professor Jean Harry, who led the study at the National Institute of Environmental Health Sciences in the United States. "This could help us develop a therapeutic approach for early intervention in preventing damage to the brain."

Previous research has already demonstrated that exercise after brain injury can help the repair mechanisms. This new study shows that exercise before the onset of damage modifies the brain environment in such a way that the neurons are protected from severe insults. The study used an experimental model of brain damage, in which mice are exposed to a chemical that destroys the hippocampus, an area of the brain which controls learning and memory. Mice that were exercised regularly prior to exposure produced an immune messenger called interleukin-6 in the brain, which dampens the harmful inflammatory response to this damage, and prevents the loss of function that is usually observed.

Pharmacological therapies to downregulate inflammation and address cognitive decline in older adults, and those with Alzheimer's disease, have been less successful. This research helps understand how exercise could be used to affect the path of many human conditions, such as neurodevelopmental disorders and neurodegenerative diseases. In addition, as a chemical model of neuronal damage was used, it also raises the possibility that exercise could offer protection against the potentially harmful effects of environmental toxins.

"This elegant series of experiments reveals an alternative pathway by which voluntary physical exercise may protect hippocampal neurons," said Dr. Ruth Barrientos from the Department of Psychology and Neuroscience at the University of Colorado. "The study on the role of exercise as a therapeutic intervention will undoubtedly get a workout in the years to come. Perhaps the greatest challenge with this line of research will not be more discoveries of compelling evidence of the anti-neuroinflammatory effects of exercise, but instead, getting humans to exercise voluntarily and regularly."

The research was funded by the Division of Intramural Research, National Institute of Environmental Health Sciences, and the National Institutes of Health.


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jason A. Funk, Julia Gohlke, Andrew D. Kraft, Christopher A. McPherson, Jennifer B. Collins, G. Jean Harry. Voluntary exercise protects hippocampal neurons from trimethyltin injury: Possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity. Brain, Behavior, and Immunity, 2011; 25 (6): 1063 DOI: 10.1016/j.bbi.2011.03.012

Cite This Page:

Elsevier. "Exercise may help prevent brain damage caused by Alzheimer's disease." ScienceDaily. ScienceDaily, 15 August 2011. <www.sciencedaily.com/releases/2011/08/110815095727.htm>.
Elsevier. (2011, August 15). Exercise may help prevent brain damage caused by Alzheimer's disease. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2011/08/110815095727.htm
Elsevier. "Exercise may help prevent brain damage caused by Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2011/08/110815095727.htm (accessed April 24, 2014).

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