Featured Research

from universities, journals, and other organizations

Kidney drugs hampered by high blood phosphate; Lowering phosphate levels could help prevent kidney failure, study suggests

Date:
August 19, 2011
Source:
American Society of Nephrology
Summary:
High blood phosphate levels can set chronic kidney disease (CKD) patients on a rapid path to kidney failure, according to a new study. To make matters worse, phosphate appears to interfere with the effectiveness of important kidney medications.

High blood phosphate levels can set chronic kidney disease (CKD) patients on a rapid path to kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). To make matters worse, phosphate appears to interfere with the effectiveness of important kidney medications.

The kidneys of patients with CKD cannot efficiently get rid of wastes such as excess phosphate in the blood. As a result, the kidneys become overloaded with phosphate. Carmine Zoccali, MD (CNR-IBIM, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension of Reggio Calabria, Italy) and his colleagues wondered how this phosphate overload affects the kidneys of patients with CKD. They also wondered whether phosphate overload alters the effects of ramipril, a drug prescribed to slow the progression of kidney disease. (The use of ramipril and other drugs in its class represents the current standard of care for patients with CKD.)

The researchers studied health information from 331 CKD patients, dividing patients into four groups based on their phosphate levels.

Among the major findings:

  • Even though their blood phosphate was still normal or near normal, patients in the two highest phosphate groups progressed more quickly to serious kidney dysfunction or kidney failure than patients with lower phosphate levels.
  • Higher phosphate levels blunted ramipril's benefits.

These results suggest that phosphate levels can predict which CKD patients are in serious trouble of developing kidney failure. They also show that high phosphate levels block the beneficial effects of important kidney medications.

Future studies should test whether reducing phosphate improves kidney health and optimizes patients' medications. "Our study opens the exciting possibility that reducing phosphate, either by diet or drug treatment, may enhance CKD patients' response to certain drugs," said Dr. Zoccali. "If our findings are replicated in a new clinical trial, interventions aimed at reducing phosphate will be a relevant step forward in the fight against these dangerous kidney diseases," he added.

Study co-authors include Piero Ruggenenti, MD, Annalisa Perna, Giuseppe Remuzzi, MD, FRCP (Mario Negri Institute for Pharmacological Research, in Bergamo, Italy); Daniela Leonardis, MD, Rocco Tripepi, Giovanni Tripepi, and Francesca Mallamaci, MD (CNR-IBIM, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension of Reggio Calabria, Italy); for the REIN Study Group.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carmine Zoccali, Piero Ruggenenti, Annalisa Perna, Daniela Leonardis, Rocco Tripepi, Giovanni Tripepi, Francesca Mallamaci, Giuseppe Remuzzi, and for the REIN Study Group. Phosphate May Promote CKD Progression and Attenuate Renoprotective Effect of ACE Inhibition. Journal of the American Society Nephrology, 2011; DOI: 10.1681/ASN.2011020175

Cite This Page:

American Society of Nephrology. "Kidney drugs hampered by high blood phosphate; Lowering phosphate levels could help prevent kidney failure, study suggests." ScienceDaily. ScienceDaily, 19 August 2011. <www.sciencedaily.com/releases/2011/08/110818190557.htm>.
American Society of Nephrology. (2011, August 19). Kidney drugs hampered by high blood phosphate; Lowering phosphate levels could help prevent kidney failure, study suggests. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2011/08/110818190557.htm
American Society of Nephrology. "Kidney drugs hampered by high blood phosphate; Lowering phosphate levels could help prevent kidney failure, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/08/110818190557.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Obama: Ebola Outbreak Threat to Global Security

Obama: Ebola Outbreak Threat to Global Security

AP (Sep. 16, 2014) President Obama is ordering U.S. military personnel to West Africa to deal with the Ebola outbreak, which is he calls a potential threat to global security. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins