Featured Research

from universities, journals, and other organizations

Differences in cell response could explain higher rates of hypertension in African-Americans

Date:
August 29, 2011
Source:
Temple University
Summary:
A kinesiology professor has found that differences in the way African-American cells respond to inflammation could be a cause of higher rates of hypertension among this group.

A key difference in the way that cells from African-Americans respond to inflammation could be an answer to why this group is disproportionately affected by hypertension, something that has eluded scientists for many years.

Related Articles


In a study published this month in Vascular Health and Risk Management, lead author Michael Brown and his team tested the effects of TNF-ά, a protein that causes inflammation when cells are damaged, on endothelial cells -- which line blood vessels -- in both African-Americans and Caucasians, to determine whether the inflammation affected the cells differently.

Among African-American cells, there was a nearly 90 percent increase in the production of endothelial microparticles, small vesicles that are released during inflammation. Individuals with hypertension have been shown to have higher levels of these microparticles in their bloodstream. Among Caucasians, there was only an eight percent increase in their production.

Brown said that although follow-up research needed to be done, "it appears that the endothelial cells in African Americans are more susceptible to the damaging effects of this inflammation." Brown is the director of the Hypertension Molecular and Applied Physiology Laboratory at Temple's College of Health Professions and Social Work.

Brown's research is unique in that it focuses on studying risk of hypertension at the cellular level; most research focuses on the clinical or physiological aspect. For more than 10 years, Brown has been trying to unlock the genetic reason behind the higher rates of hypertension and cardiovascular disease among African Americans.

Brown's research includes an exercise component, to test whether physical activity can reverse or prevent the damage done by hypertension at the cellular level.

"In our human study we have pre-hypertensive African-Americans, and we find this level of endothelial impairment. Knowing so early how inflammation can affect cells means we can be at a place to intervene before they go on to develop hypertension," said Brown. "That intervention could be lifestyle modification, diet and exercise to improve vascular health."

Other authors on this study are Deborah Feairheller, Sunny Thakkar, Praveen Veerabhadrappa and Joon-Young Park of the department of kinesiology. Funding for this study was provided by the National Heart Lung and Blood Institute at the National Institutes of Health.


Story Source:

The above story is based on materials provided by Temple University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael Brown, Michael Brown, Deborah Feairheller, Thakkar, Park. Racial differences in tumor necrosis factor-α-induced endothelial microparticles and interleukin-6 production. Vascular Health and Risk Management, 2011; 541 DOI: 10.2147/VHRM.S22930

Cite This Page:

Temple University. "Differences in cell response could explain higher rates of hypertension in African-Americans." ScienceDaily. ScienceDaily, 29 August 2011. <www.sciencedaily.com/releases/2011/08/110829164655.htm>.
Temple University. (2011, August 29). Differences in cell response could explain higher rates of hypertension in African-Americans. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2011/08/110829164655.htm
Temple University. "Differences in cell response could explain higher rates of hypertension in African-Americans." ScienceDaily. www.sciencedaily.com/releases/2011/08/110829164655.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins