Featured Research

from universities, journals, and other organizations

Ultrasound improves stem cell transplants, Swedish researchers discover

Date:
September 7, 2011
Source:
Lund University
Summary:
Transplantation of hematopoietic stem cells is an effective treatment for patients with malignant blood diseases. The composition and quality of the transplanted cells are crucial to the outcome. Researchers from Sweden have now developed a method to improve the quality of the transplanted cells using ultrasound for cell separation.

Transplantation of hematopoietic stem cells is an effective treatment for patients with malignant blood diseases. The composition and quality of the transplanted cells are crucial to the outcome. Researchers from Lund University, Sweden, have now developed a method to improve the quality of the transplanted cells using ultrasound for cell separation.

For patients with blood cancer, a blood stem cell transplant is often the only treatment that can cure the disease. The quality of the transplanted blood stem cells and the choice and composition of the transplanted cells can be crucial.

Current methods of collecting and processing stem cell products leave a lot to be desired. Recent results from Lund University indicate that it may be possible to considerably improve the quality of the blood stem cell product by using a method known as acoustic cell separation.

"The method was developed in the field of microtechnology and builds on basic engineering research from Lund University," explains Professor Thomas Laurell, research group leader at the Faculty of Engineering. The method is expected to facilitate improvements in the processing of blood stem cells.

Associate Professor Stefan Scheding, senior consultant at the Department of Haematology at Skåne University Hospital and research group leader at the Stem Cell Centre at Lund University, is in charge of the preclinical development of the new method, which aims to effectively separate and possibly remove or concentrate cell populations which are normally found in standard blood stem cells products. The first step has been to show that the method works, by separating out platelets from stem cell products.

"Our hope is that it will become possible to produce the optimal stem cell product for each individual transplant patient," says Stefan Scheding. "This would give us a good chance of improving the treatment of patients who would otherwise be at risk of suffering from serious transplant complications, such as graft-versus-host disease and infections. By optimising the quality of the transplanted cells, it may even be possible to better fight the leukemia cells that remain in the body despite the transplant treatment," he explains.

The project is part of the research programme CellCare, which is funded by the Swedish Governmental Agency for Innovation Systems (Vinnova) and coordinated by Thomas Laurell.


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Josefina Dykes, Andreas Lenshof, Ing-Britt Åstrand-Grundström, Thomas Laurell, Stefan Scheding. Efficient Removal of Platelets from Peripheral Blood Progenitor Cell Products Using a Novel Micro-Chip Based Acoustophoretic Platform. PLoS ONE, 2011; 6 (8): e23074 DOI: 10.1371/journal.pone.0023074

Cite This Page:

Lund University. "Ultrasound improves stem cell transplants, Swedish researchers discover." ScienceDaily. ScienceDaily, 7 September 2011. <www.sciencedaily.com/releases/2011/09/110906085218.htm>.
Lund University. (2011, September 7). Ultrasound improves stem cell transplants, Swedish researchers discover. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2011/09/110906085218.htm
Lund University. "Ultrasound improves stem cell transplants, Swedish researchers discover." ScienceDaily. www.sciencedaily.com/releases/2011/09/110906085218.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) — A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins