Featured Research

from universities, journals, and other organizations

Biomaterials may prove key to healing chronic wounds in diabetic patients

Date:
September 6, 2011
Source:
National University of Ireland, Galway
Summary:
Biomaterials may prove key to healing chronic wounds in diabetic patients, new research suggests.

Biomaterials may prove key to healing chronic wounds in Diabetic patients, delegates will hear September 6 at the 24th European Conference on Biomaterials. Over 950 delegates are at the event in Dublin, which is jointly hosted by NUI Galway's Network of Excellence for Functional Biomaterials and the University of Ulster, Jordanstown.

Delivering therapeutic genes using a new biomaterial-based delivery system to the site of chronic wounds in diabetes patients may enhance wound healing. Researchers at the Network of Excellence for Functional Biomaterials (NFB) at NUI Galway hope that technology being developed at the University may reduce the rate of limb amputation and morbidity in diabetic patients.

Diabetes related chronic wounds and subsequent lower limb amputation are major causes of morbidity in diabetic patients, incurring enormous medical, economic and social burden. The rigorous treatment regimes in clinics have had only modest success in lowering the overall amputation rate.

The major reason behind the failure is rooted in the fact that diabetes affects all the wound healing cells not only functionally but also genetically. This molecular disarray is not completely understood yet, so treatment regimes aimed at rectifying the genetic problem are needed for tangible therapeutic benefit.

Researchers at the NFB are working on a project investigating the genetic dysregulation but also combined novel and complementary genes to normalize wound healing.

The work has found that success of the gene therapy depends largely on how it is delivered. The gene delivery system developed gives a protective scaffold and also allows controlled delivery with components carrying different genes and degrading at different rates. The gene delivery method is, in effect, micron-size spheres embedded in mesh made from protein fibers, a tiny but very complex biomaterial product.

Overall results are very encouraging with enhanced wound closure, complemented by increased blood vessel formation and reduced inflammation.

According to the NFB's Mangesh Kulkarni, "We envision that the combined new gene therapy and delivery system can aid in reducing the amputation rate by enhancing wound healing. This has the potential to make a real change when applied to chronic diabetic wounds. Since the components of the system have a relatively good safety profile, clinical trials can be conducted to prove the therapeutic benefit in human patients."


Story Source:

The above story is based on materials provided by National University of Ireland, Galway. Note: Materials may be edited for content and length.


Cite This Page:

National University of Ireland, Galway. "Biomaterials may prove key to healing chronic wounds in diabetic patients." ScienceDaily. ScienceDaily, 6 September 2011. <www.sciencedaily.com/releases/2011/09/110906104837.htm>.
National University of Ireland, Galway. (2011, September 6). Biomaterials may prove key to healing chronic wounds in diabetic patients. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2011/09/110906104837.htm
National University of Ireland, Galway. "Biomaterials may prove key to healing chronic wounds in diabetic patients." ScienceDaily. www.sciencedaily.com/releases/2011/09/110906104837.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins