Featured Research

from universities, journals, and other organizations

Hyperventilation may trigger febrile seizures in children; Controlling acid-base status could lead to novel treatment strategies

Date:
September 12, 2011
Source:
Wiley-Blackwell
Summary:
New research shows that febrile seizures in children may be linked to respiratory alkalosis, indicated by elevated blood pH and low carbon dioxide levels caused by hyperventilation, and independent of the underlying infection severity. Febrile seizures were not observed in susceptible children with fevers brought on by gastroenteritis, suggesting that low blood pH levels (acidosis) may have a protective effect.

New research shows that febrile seizures in children may be linked to respiratory alkalosis, indicated by elevated blood pH and low carbon dioxide levels caused by hyperventilation, and independent of the underlying infection severity. Febrile seizures were not observed in susceptible children with fevers brought on by gastroenteritis, suggesting that low blood pH levels (acidosis) may have a protective effect. Full findings now appear in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE).

Febrile seizures are the most common type of convulsive disorder in children, affecting nearly 1 out of every 25 children and typically occurring between the ages of 6 months and 5 years, according to the National Institute of Neurological Disorders and Stroke (NINDS). Previous studies have suggested that a combination of genetic and environmental factors cause febrile seizures which have an incidence of up to 8% depending on geographical region and culture.

To further understand the functional changes associated with febrile seizures, a team of investigators, led by Dr. Sebastian Schuchmann, at the Charité-Universitätsmedizin Berlin in Germany and the University of Helsinki in Finland enrolled and analysed 433 children with similar fever levels who were admitted to hospital for febrile seizure (n=213) or gastroenteritis (n=220). All pediatric patients had their blood pH and carbon dioxide levels measured upon admission.

Researchers found respiratory alkalosis in children with febrile seizures and metabolic acidosis in pediatric patients admitted for gastroenteritis. Febrile seizures did not occur in children with gastroenteritis, except in a subgroup of 15 patients who had an alkaline blood pH level. Additionally, 8 patients were admitted on separate occasions for febrile seizures and gastroenteritis; blood pH was elevated when the child was admitted with febrile seizure, but a more acidotic pH was found when the child presented with gastroenteritis.

"Our findings reveal that febrile seizures are associated with respiratory alkalosis and unrelated to the severity of the underlying infection or fever level," concluded Dr. Schuchmann. "Further investigation of methods that control the body's acid-base status may lead to the development of novel therapies for treating febrile seizures." Based on the study results, the authors suggest an application of 5% carbon dioxide in the breathing air as a possible treatment for febrile seizures.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sebastian Schuchmann, Sarah Hauck, Stephan Henning, Annette Grüters-Kieslich, Sampsa Vanhatalo, Dietmar Schmitz, Kai Kaila. Respiratory Alkalosis in Children with Febrile Seizures. Epilepsia, 2011; DOI: 10.1111/j.1528-1167.2011.03259.x

Cite This Page:

Wiley-Blackwell. "Hyperventilation may trigger febrile seizures in children; Controlling acid-base status could lead to novel treatment strategies." ScienceDaily. ScienceDaily, 12 September 2011. <www.sciencedaily.com/releases/2011/09/110912075652.htm>.
Wiley-Blackwell. (2011, September 12). Hyperventilation may trigger febrile seizures in children; Controlling acid-base status could lead to novel treatment strategies. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/09/110912075652.htm
Wiley-Blackwell. "Hyperventilation may trigger febrile seizures in children; Controlling acid-base status could lead to novel treatment strategies." ScienceDaily. www.sciencedaily.com/releases/2011/09/110912075652.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) — Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) — Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) — According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) — The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins