Featured Research

from universities, journals, and other organizations

Bursting neurons follow the same beat, sometimes

Date:
September 12, 2011
Source:
American Institute of Physics
Summary:
Researchers have created a mathematical model that captures the intermittent nature of synchronization in neural networks, lending insight into the mechanisms behind diseases such as Parkinson's.

A simplified mathematical model of the brain's neural circuitry shows that repetitious, overlapped firing of neurons can lead to the waves of overly synchronized brain activity that may cause the halting movements that are a hallmark of Parkinson's disease.

Related Articles


The model provides a tool in the quest to gain a better understanding of the mechanisms behind this incurable degenerative disorder.

Researchers from IUPUI (Indiana University-Purdue University Indianapolis) reduced the complex biology of the basal ganglia, a part of the brain involved in voluntary motor control, down to a key system of two interconnected cells. The cells were linked together in an inhibitory relationship, meaning a signal from one cell would suppress the second cell's firing. The team ran simulations of the two-cell system while tinkering with the parameters of the model. For example, since levels of the neurotransmitter dopamine decrease in Parkinson's patients, increasing the inhibitory coupling strength between cells, the team tested how the strength of the inhibitory connection affected the cells' synchronization.

In a paper in the AIP's journal Chaos, the researchers identified specific ranges of coupling strength most likely to lead to bursts of intermittently synchronized firings.

The team also produced squiggly-lined graphs showing how the complex interactions between slow-changing variables such as calcium ion concentration can cause intermittent synchronization of the two cells. Although the model is based on a neural network known to be affected by Parkinson's disease, the authors believe that their mathematical model might also yield insights into the operation of more generic neural systems.


Story Source:

The above story is based on materials provided by American Institute of Physics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Choongseok Park, Leonid L Rubchinsky. Possible mechanisms underlying intermittent synchronous activity in the networks of excitatory and inhibitory bursting neurons. BMC Neuroscience, 2011; 12 (Suppl 1): P276 DOI: 10.1186/1471-2202-12-S1-P276

Cite This Page:

American Institute of Physics. "Bursting neurons follow the same beat, sometimes." ScienceDaily. ScienceDaily, 12 September 2011. <www.sciencedaily.com/releases/2011/09/110912143410.htm>.
American Institute of Physics. (2011, September 12). Bursting neurons follow the same beat, sometimes. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2011/09/110912143410.htm
American Institute of Physics. "Bursting neurons follow the same beat, sometimes." ScienceDaily. www.sciencedaily.com/releases/2011/09/110912143410.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins