Featured Research

from universities, journals, and other organizations

Bursting neurons follow the same beat, sometimes

Date:
September 12, 2011
Source:
American Institute of Physics
Summary:
Researchers have created a mathematical model that captures the intermittent nature of synchronization in neural networks, lending insight into the mechanisms behind diseases such as Parkinson's.

A simplified mathematical model of the brain's neural circuitry shows that repetitious, overlapped firing of neurons can lead to the waves of overly synchronized brain activity that may cause the halting movements that are a hallmark of Parkinson's disease.

The model provides a tool in the quest to gain a better understanding of the mechanisms behind this incurable degenerative disorder.

Researchers from IUPUI (Indiana University-Purdue University Indianapolis) reduced the complex biology of the basal ganglia, a part of the brain involved in voluntary motor control, down to a key system of two interconnected cells. The cells were linked together in an inhibitory relationship, meaning a signal from one cell would suppress the second cell's firing. The team ran simulations of the two-cell system while tinkering with the parameters of the model. For example, since levels of the neurotransmitter dopamine decrease in Parkinson's patients, increasing the inhibitory coupling strength between cells, the team tested how the strength of the inhibitory connection affected the cells' synchronization.

In a paper in the AIP's journal Chaos, the researchers identified specific ranges of coupling strength most likely to lead to bursts of intermittently synchronized firings.

The team also produced squiggly-lined graphs showing how the complex interactions between slow-changing variables such as calcium ion concentration can cause intermittent synchronization of the two cells. Although the model is based on a neural network known to be affected by Parkinson's disease, the authors believe that their mathematical model might also yield insights into the operation of more generic neural systems.


Story Source:

The above story is based on materials provided by American Institute of Physics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Choongseok Park, Leonid L Rubchinsky. Possible mechanisms underlying intermittent synchronous activity in the networks of excitatory and inhibitory bursting neurons. BMC Neuroscience, 2011; 12 (Suppl 1): P276 DOI: 10.1186/1471-2202-12-S1-P276

Cite This Page:

American Institute of Physics. "Bursting neurons follow the same beat, sometimes." ScienceDaily. ScienceDaily, 12 September 2011. <www.sciencedaily.com/releases/2011/09/110912143410.htm>.
American Institute of Physics. (2011, September 12). Bursting neurons follow the same beat, sometimes. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2011/09/110912143410.htm
American Institute of Physics. "Bursting neurons follow the same beat, sometimes." ScienceDaily. www.sciencedaily.com/releases/2011/09/110912143410.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins