Lifestyle modifications and pharmaceutical treatment of risk factors for cardiovascular disease are associated with improvement in sexual function among men with erectile dysfunction (ED), according to a meta-analysis posted Online First in Archives of Internal Medicine, one of the JAMA/Archives journals.
"Erectile dysfunction shares modifiable risks factors with atherosclerosis and coronary artery disease (CAD), including hypertension, diabetes, dyslipidemia, cigarette smoking, obesity, metabolic syndrome, and sedentary behavior," according to background information in the article. "Erectile dysfunction has a high prevalence in individuals with multiple cardiovascular (CV) risk factors and is an independent predictor or CV events and may serve as the sentinel marker for CV disease (CVD)."
Bhanu P. Gupta, M.D., and colleagues with the Mayo Clinic, Rochester, Minn., conducted a meta-analysis of six previous randomized controlled trials from four countries to evaluate the effects of lifestyle intervention and pharmaceutical treatment of cardiovascular risk factors on the severity of ED.
The six trials examined in the meta-analysis included a total of 740 participants, with the number of participants per trial ranging from 12 to 372. Average age of the participants was 55.4 years and the study duration ranged from 12 to 104 weeks. All studies included in the analysis showed improvement in ED with lifestyle changes and improvement in blood lipid parameters.
The authors found that improvement in CV risk factors was associated with statistically significant improvement in sexual function in men with ED. When trials using pharmaceutical treatment were excluded and only studies using lifestyle interventions were examined, the improvement in sexual function was still statistically significant. Pharmaceutical treatment targeting CV risk factors also demonstrated improvement in sexual function.
"In summary, this study further strengthens the evidence of improvement in ED and maintenance of sexual function with lifestyle intervention and CV risk factor reduction," the authors write. "Men with ED provide an opportunity to identify CV risk factors and initiate lifestyle changes."
Commentary: Quality of Lifestyle and Quality of Life
In an accompanying commentary, Militza Moreno, M.D., and Thomas A. Pearson, M.D., M.P.H., Ph.D., both of the University of Rochester School of Medicine and Dentistry, New York, discuss the link between a healthy lifestyle and quality of life, writing, "the number of health benefits that accrue to persons with healthy lifestyles continue to increase in number and importance."
Moreno and Pearson also note that the meta-analysis conducted by Gupta et al shows the "meaningful benefits of healthy lifestyle on cerebrovascular disease and erectile dysfunction." They continue to say that, "the increasing epidemic of obesity in the United States is a clarion call to step up our efforts to motivate our patients and the public at large to make even small changes toward healthier lifestyles. These new associations between healthy lifestyles and reducing incidence of stroke, congestive heart failure, and ED can add additional powerful persuaders."
"The cost of hospital admissions, physician visits, and pharmacotherapy for stroke and ED are certainly enormous," they write. "Both clinicians and public health practitioners should be reassured that the benefits of their lifestyle modification efforts are overwhelmingly positive and continue to grow, and we should renew our efforts to help patients add life to the years, as well as years to life."
- Bhanu P. Gupta; M. Hassan Murad; Marisa M. Clifton; Larry Prokop; Ajay Nehra; Stephen L. Kopecky. The Effect of Lifestyle Modification and Cardiovascular Risk Factor Reduction on Erectile Dysfunction: A Systematic Review and Meta-analysis. Archives of Internal Medicine, 2011; DOI: 10.1001/archinternmed.2011.440
- Militza Moreno; Thomas A. Pearson. The Quality of Lifestyle and the Quality of Life: Comment on 'The Effect of Lifestyle Modification and Cardiovascular Risk Factor Reduction on Erectile Dysfunction'. Archives of Internal Medicine, 2011; DOI: 10.1001/archinternmed.2011.442
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