Featured Research

from universities, journals, and other organizations

New invention unravels mystery of protein folding

Date:
September 14, 2011
Source:
DOE/Oak Ridge National Laboratory
Summary:
A new invention able to quickly predict three-dimensional structure of protein could have huge implications for drug discovery and human health.

An Oak Ridge National Laboratory invention able to quickly predict three-dimensional structure of protein could have huge implications for drug discovery and human health.

Related Articles


While scientists have long studied protein structure and the mechanism of folding, this marks the first time they are able to computationally predict three-dimensional structure independent of size of the protein. Because the invention also determines possible intermediate states in the protein folding process, it provides a clearer picture and could open doors to designing new medicines for neurodegenerative diseases that are caused by incorrectly folded proteins.

Pratul Agarwal, inventor of the method and a member of the Department of Energy lab's Computer Science and Mathematics Division, believes this new method will provide benefits in many areas.

"This finding is relevant to energy, climate and health, which are all of tremendous significance today," Agarwal said. "We expect this approach to have many industrial applications through protein engineering, for example, where we expect to be able to design more efficient enzymes."

Proteins often adopt a three-dimensional structure that allows them to carry out their designated function, but such a structure has provided a computationally challenging task. Using the fundamental insights of the protein structure, dynamics and function, the ORNL invention discloses a unique computational methodology to explore the conformational energy landscape of a protein.

"One of the main advantages of this approach is that it follows the natural intrinsic dynamics of the protein and by promoting the relevant dynamical modes allows rapid exploration of the folding pathway and prediction of the protein structure," Agarwal said.

In the area of drug development, Agarwal, a computational biophysicist, expects this discovery to help in the development of treatments with little or no side effects.

Funding for this research has been provided by the National Institutes of Health, Battelle Memorial Institute and the ORNL Laboratory Directed Research and Development program. Patent No. 7,983,887, "Fast computational methods for mechanism of protein folding and prediction of protein structure from primary sequence," was issued to Agarwal in July 2011.


Story Source:

The above story is based on materials provided by DOE/Oak Ridge National Laboratory. Note: Materials may be edited for content and length.


Journal References:

  1. Arvind Ramanathan, Andrej J. Savol, Christopher J. Langmead, Pratul K. Agarwal, Chakra S. Chennubhotla. Discovering Conformational Sub-States Relevant to Protein Function. PLoS ONE, 2011; 6 (1): e15827 DOI: 10.1371/journal.pone.0015827
  2. Jose M. Borreguero, Junhong He, F. Meilleur, Kevin L. Weiss, Craig M. Brown, Dean A. Myles, Kenneth W. Herwig, Pratul K. Agarwal. Redox-Promoting Protein Motions in Rubredoxin. The Journal of Physical Chemistry B, 2011; 115 (28): 8925 DOI: 10.1021/jp201346x

Cite This Page:

DOE/Oak Ridge National Laboratory. "New invention unravels mystery of protein folding." ScienceDaily. ScienceDaily, 14 September 2011. <www.sciencedaily.com/releases/2011/09/110914131357.htm>.
DOE/Oak Ridge National Laboratory. (2011, September 14). New invention unravels mystery of protein folding. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2011/09/110914131357.htm
DOE/Oak Ridge National Laboratory. "New invention unravels mystery of protein folding." ScienceDaily. www.sciencedaily.com/releases/2011/09/110914131357.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Reuters - US Online Video (Apr. 17, 2015) A truck carrying honey bees overturns near Lynnwood, Washington, spreading boxes of live bees across the highway. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dog Flu Spreading in Midwestern States

Dog Flu Spreading in Midwestern States

AP (Apr. 17, 2015) Dog flu is spreading in several Midwestern states. Dog daycare centers and veterinary offices are taking precautions. (April 17) Video provided by AP
Powered by NewsLook.com
Raw: Rare Whale Spotted in Gulf of Mexico

Raw: Rare Whale Spotted in Gulf of Mexico

AP (Apr. 17, 2015) Researchers from the E/V Nautilus had quite a surprise Tuesday, when a curious sperm whale swam around their remotely operated vehicle in the Gulf of Mexico. Cameras captured the encounter. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins