Featured Research

from universities, journals, and other organizations

Pregnant women who exercise protect their offspring against long-term neurodegenerative diseases, study suggests

Date:
September 29, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
If you are pregnant, here's another reason to work out: you will reduce the chances of your baby developing neurodegenerative diseases, such as Alzheimer's, later in life, new research suggests. A new report shows that mice bred to develop a neurodegenerative disease equivalent to Alzheimer's disease showed fewer signs of the disease and greater brain plasticity later in life when their mothers exercised regularly than those whose mothers did not.

If you are pregnant, here's another reason to work out: you will reduce the chances of your new baby developing neurodegenerative diseases, such as Alzheimer's, later in life. A new research report published online in The FASEB Journal shows that mice bred to develop a neurodegenerative disease roughly equivalent to Alzheimer's disease showed fewer signs of the disease and greater brain plasticity later in life when their mothers exercised regularly than those whose mothers did not exercise.

"This research provides an experimental rationale for the effects of beneficial behavioral stimuli experienced by the pregnant mother affecting the disease status of an as yet-unborn child. Epigenetic alterations (alterations in gene and protein expression caused by mechanisms other than changes in the underlying DNA sequence) provide a most probable mechanism by which mothers could have transferred their own behavioral experience to their progeny," said Kathy Keyvani, M.D., a researcher involved in the work from the Institute of Pathology and Neuropathology at the University Hospital Essen in Essen, Germany. "A better understanding of the underlying pathways may provide novel treatment and/or prevention strategies for Alzheimer's disease and bring more insight into the fascinating link between brain and behavior."

To make this discovery, Keyvani and colleagues mated male mice that express a mutant form of the APP gene found in some Alzheimer's patients with healthy female wild-type mice. After weaning, healthy and "Alzheimer-diseased" offspring were kept in standard cages for five months. Mouse brains were examined for signs of disease shortly thereafter. The "Alzheimer-diseased" mice whose mothers ran on a exercise wheel during pregnancy had fewer Beta-amyloid plaques, smaller plaque size, less inflammation, less oxidative stress, and a better functioning vascular network than those whose mothers did not run. Additionally, the mice whose mothers ran on the wheel also showed an up-regulation of plasticity-related molecules, which are indicators for more and better connections between the nerve cells.

"No one is resistant to the health benefits of exercise," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "and this research confirms that reasonable workouts can have a lifetime of benefits for your offspring. Whether you work out at home or go to the gym, you should do it for the sake of your health and that of your offspring."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Herring, A. Donath, M. Yarmolenko, E. Uslar, C. Conzen, D. Kanakis, C. Bosma, K. Worm, W. Paulus, K. Keyvani. Exercise during pregnancy mitigates Alzheimer-like pathology in mouse offspring. The FASEB Journal, 2011; DOI: 10.1096/fj.11-193193

Cite This Page:

Federation of American Societies for Experimental Biology. "Pregnant women who exercise protect their offspring against long-term neurodegenerative diseases, study suggests." ScienceDaily. ScienceDaily, 29 September 2011. <www.sciencedaily.com/releases/2011/09/110926104605.htm>.
Federation of American Societies for Experimental Biology. (2011, September 29). Pregnant women who exercise protect their offspring against long-term neurodegenerative diseases, study suggests. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2011/09/110926104605.htm
Federation of American Societies for Experimental Biology. "Pregnant women who exercise protect their offspring against long-term neurodegenerative diseases, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/09/110926104605.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins