Featured Research

from universities, journals, and other organizations

Increased risk of bleeding with combined use of SSRIs and antiplatelet therapy after heart attacks

Date:
September 26, 2011
Source:
Canadian Medical Association Journal
Summary:
Heart attack patients taking selective serotonin reuptake inhibitors (SSRIs) in combination with antiplatelet therapy -- acetylsalicylic acid (ASA), clopidogrel or both (dual antiplatelet therapy) -- are at higher risk of bleeding than patients taking ASA alone, according to a study in CMAJ.

Heart attack patients taking selective serotonin reuptake inhibitors (SSRIs) in combination with antiplatelet therapy -- acetylsalicylic acid (ASA), clopidogrel or both (dual antiplatelet therapy) -- are at higher risk of bleeding than patients taking ASA alone, according to a study in CMAJ (Canadian Medical Association Journal).

Antiplatelet therapy is commonly prescribed for patients who have had heart attacks to reduce the likelihood of another attack. There is, however, a risk of bleeding, which increases when certain other medications such as anticoagulants or SSRIs are taken at the same time as antiplatelet therapy.

SSRIs are commonly prescribed for depression. Many patients have symptoms of depression after a heart attack.

The study in CMAJ looked at 27 058 patients aged 50 years or older between 1997 and 2007. More than half were taking ASA alone and about 3% were taking SSRIs along with antiplatelet therapy. Researchers found that although ASA and clopidogrel taken on their own have a similar risk of bleeding, combining an SSRI with ASA increased the risk by 42%, and combining SSRI use with dual antiplatelet therapy increased the risk by 57%. Women appeared to have a decreased risk of bleeding, as did patients who had angioplasty as an intervention after their heart attack.

Bleeding includes gastrointestinal bleeding, hemorrhagic stroke or other bleeding that required hospitalization or occurred in hospital during treatment.

"Ultimately, clinicians must weigh the benefits of SSRI therapy against the risk of bleeding in patients with major depression following acute myocardial infarction," write the authors. They conclude physicians must be cautious when prescribing antidepressants.


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christopher Labos, Kaberi Dasgupta, Hacene Nedjar, Gustavo Turecki, Elham Rahme. Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction. Canadian Medical Association Journal, September 26, 2011 DOI: 10.1503/cmaj.100912

Cite This Page:

Canadian Medical Association Journal. "Increased risk of bleeding with combined use of SSRIs and antiplatelet therapy after heart attacks." ScienceDaily. ScienceDaily, 26 September 2011. <www.sciencedaily.com/releases/2011/09/110926131802.htm>.
Canadian Medical Association Journal. (2011, September 26). Increased risk of bleeding with combined use of SSRIs and antiplatelet therapy after heart attacks. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2011/09/110926131802.htm
Canadian Medical Association Journal. "Increased risk of bleeding with combined use of SSRIs and antiplatelet therapy after heart attacks." ScienceDaily. www.sciencedaily.com/releases/2011/09/110926131802.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins