Featured Research

from universities, journals, and other organizations

Novel tool for myocardial infarction quantification: Step toward speeding the evaluation of novel therapies for heart regeneration

Date:
September 30, 2011
Source:
IBMC.INEB Associate Laboratory
Summary:
A team of scientists in Portugal has developed an original tool to quantify the size of heart ischemia in pre-clinical animal models. The MIQuant, an acronym for myocardial infarct (MI) quantification, is user-friendly semi-automated software and is made freely available online to contribute towards the standardization and simplification of infarct size assessment. This innovation takes advantage of earlier methods of planimetry for assessment of MI size and promises more accurate and faster evaluation of new heart regeneration therapies.

A team of scientists from INEB-Instituto de Engenharia Biomédica has developed an original tool to quantify the size of heart ischemia in pre-clinical animal models. The MIQuant, acronym for myocardial infarct (MI) quantification, is user-friendly semi-automated software and is made freely available online to contribute towards the standardization and simplification of infarct size assessment. This innovation takes advantage of earlier methods of planimetry for assessment of MI size and promises more accurate and faster evaluation of new heart regeneration therapies.

As team leader Perpétua Pinto-do-Ó, Ph.D., of INEB explains, "This development is a great illustration of where communication between different scientific languages can lead us. Sometimes biologists, physicians and engineers waste the opportunity for novel improvements due to the difficulties to translate their problems and questions. It took us time, but we found here just the right platform to smoothen our differences which resulted in an application that will be useful not only to our Lab but to the whole of the experimental cardiovascular community."

Diana S. Nascimento, PhD, first author to the paper published September 30 in PLoS ONE online, summed it up: "At the time we were implementing from scratch our work in the cardiac system and it was after establishing a mouse model of myocardial infarction that we were confronted with the huge amount of time and variability on the infarct analysis. We just had to take some action!"

Therefore, the team started two years ago -- in collaboration with Pedro Quelhas, Ph.D., INEB-FEUP -- designing a tool to address the main constrains found while developing research on the role of stem/progenitors cells have on cardiac regeneration and repair: the laborious time-consuming and highly variable methods available for the assessment of infarct size measurements in a mouse model of myocardial infarction. The purpose has been to automate the process just enough to promote standardization. From the discussion within this multidisciplinary project it was evident that a semi-automated method allowing for some kind of intervening by the biologist was more likely to be accepted in the area. However, the engineers in the team do not exclude future developments towards the full automation. These and a few other improvements on the pipeline will deserve attention and be tested by using the in vivo data in Pinto-do-Ó' Team.

"Basically, any laboratory that works in experimental cardiovascular therapies using small rodents as models can take profit of the MIQuant software. In this way we expect to contribute towards the standardization of infarct size assessment across studies and, therefore, to systematization of the evaluation of cardiac regenerative potential in emerging therapies," concludes Pinto-do-Ó.


Story Source:

The above story is based on materials provided by IBMC.INEB Associate Laboratory. Note: Materials may be edited for content and length.


Journal Reference:

  1. Diana S. Nascimento, Mariana Valente, Tiago Esteves, Maria de Fátima de Pina, Joana G. Guedes, Ana Freire, Pedro Quelhas, Perpétua Pinto-do-Ó. MIQuant – Semi-Automation of Infarct Size Assessment in Models of Cardiac Ischemic Injury. PLoS ONE, 2011; 6 (9): e25045 DOI: 10.1371/journal.pone.0025045

Cite This Page:

IBMC.INEB Associate Laboratory. "Novel tool for myocardial infarction quantification: Step toward speeding the evaluation of novel therapies for heart regeneration." ScienceDaily. ScienceDaily, 30 September 2011. <www.sciencedaily.com/releases/2011/09/110930082225.htm>.
IBMC.INEB Associate Laboratory. (2011, September 30). Novel tool for myocardial infarction quantification: Step toward speeding the evaluation of novel therapies for heart regeneration. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2011/09/110930082225.htm
IBMC.INEB Associate Laboratory. "Novel tool for myocardial infarction quantification: Step toward speeding the evaluation of novel therapies for heart regeneration." ScienceDaily. www.sciencedaily.com/releases/2011/09/110930082225.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) — West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) — Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins