Featured Research

from universities, journals, and other organizations

Researchers find regulatory T-cell clue to help prevent GVHD

Date:
November 28, 2011
Source:
H. Lee Moffitt Cancer Center & Research Institute
Summary:
Graft-versus-host disease (GVHD) is a serious risk in many kinds of cell transplants, including for stem cell transplants carried out when stem cells are partially depleted of conventional T cells, which play an important role in the immune system. Now, researchers have tested a process by which T regulatory cells can be "expanded" to help prevent GVHD.

Graft-versus-host disease (GVHD) is a serious risk in many kinds of cell transplants, including for stem cell transplants carried out when stem cells are partially depleted of conventional T cells, which play an important role in the immune system. Now, researchers at Moffitt Cancer Center have tested a process by which T regulatory cells (Tregs) can be "expanded" to help prevent GVHD.

"Tregs play a dominant role in transplantation tolerance," said Claudio Anasetti, M.D., corresponding author of a study carried out by a team of Moffitt investigators and published in a recent issue of the journal Blood. "Adoptive transfer of freshly isolated human Tregs has prevented GVHD in patients treated with allogeneic (other than self-donated) stem cell transplants. However, some transplants will require a greater number of Tregs that can only be obtained through expanding Tregs outside of the body."

The researchers suggest that therapeutic applications will require Tregs to be expanded by more than a hundredfold.

"There is a need to improve on Treg expansion protocols before allo-specific Tregs can be brought into the clinic," said Anasetti, chair of the Department of Blood & Marrow Transplant at Moffitt.

The authors note that a recently adopted expansion process has used dendritic cells to activate Tregs.

"Dendritic cells have been identified as having unique capabilities for expanding Tregs," cited Anasetti, whose work focuses on preventing GVHD in mouse models and in humans.

To carry out the present study, Anasetti and his fellow researchers adopted a one-step process to expand allo-specific Tregs by dendritic cell stimulation.

"Our work opens an opportunity to study tissues as sources of antigens for indirect presentation to activate and expand therapeutic Tregs," concluded Anasetti. "If effective, this approach could prevent GVHD while sparing, at least in part, graft-versus-leukemia or graft-versus-tumor responses."


Story Source:

The above story is based on materials provided by H. Lee Moffitt Cancer Center & Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Veerapathran, J. Pidala, F. Beato, X.-Z. Yu, C. Anasetti. Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly. Blood, 2011; DOI: 10.1182/blood-2011-02-337097

Cite This Page:

H. Lee Moffitt Cancer Center & Research Institute. "Researchers find regulatory T-cell clue to help prevent GVHD." ScienceDaily. ScienceDaily, 28 November 2011. <www.sciencedaily.com/releases/2011/10/111031121227.htm>.
H. Lee Moffitt Cancer Center & Research Institute. (2011, November 28). Researchers find regulatory T-cell clue to help prevent GVHD. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2011/10/111031121227.htm
H. Lee Moffitt Cancer Center & Research Institute. "Researchers find regulatory T-cell clue to help prevent GVHD." ScienceDaily. www.sciencedaily.com/releases/2011/10/111031121227.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins