Featured Research

from universities, journals, and other organizations

Researchers develop a way to monitor engineered blood vessels as they grow in patients

Date:
December 9, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
New research describes how by using magnetic resonance imaging and nanoparticle technology, scientists can monitor the growth of laboratory-engineered blood vessels after implantation in patients. This is an important step toward ensuring that blood vessels, and tissues engineered from a patient's own biological material, are taking hold and working as expected. This is the first method for monitoring the growth and progress of engineered tissues once they are implanted.

Using magnetic resonance imaging (MRI) and nanoparticle technology, researchers from Yale have devised a way to monitor the growth of laboratory-engineered blood vessels after they have been implanted in patients. This advance represents an important step toward ensuring that blood vessels, and possibly other tissues engineered from a patient's own biological material, are taking hold and working as expected. Until now, there has been no way to monitor the growth and progress of engineered tissues once they were implanted.

Related Articles


The research was published in the December 2011 issue of the FASEB Journal.

"We hope that the important findings from our study will serve as a valuable tool for physicians and scientists working to better understand the biological mechanisms involved in tissue engineering," said Christopher K. Breuer, M.D., co-author of the study from the Interdepartmental Program in Vascular Biology and Therapeutics at Yale University School of Medicine in New Haven, CT. "Resulting advances will hopefully usher in a new era of personalized medical treatments where replacement vessels are specifically designed for each patient suffering from cardiac anomalies and disease."

To make this advance, scientists used two different groups of cells to make tissue-engineered blood vessels. In the first group, the cells were labeled with the MRI contrast agent. In the second group, the cells were normal and did not have an MRI label. Cells from each group were then used to create separate laboratory-engineered blood vessels, which were implanted into mice. The purpose was to see whether the laboratory-engineered blood vessels made from cells that were labeled with the contrast agent would indeed be visible on MRI and to make sure that the addition of the contrast agent did not negatively affect the cells or the function of the laboratory-engineered vessels. Researchers imaged the mice with MRI and found that it was possible to track the cells labeled with contrast agent, but not possible to track the cells that were not labeled. This suggests that using MRI and cellular contrast agents to study cellular changes in the tissue-engineered blood vessels after they are implanted is an effective way to monitor these types of vessels.

"This is great news for patients with congenital heart defects, who have to undergo tissue grafting, but that's only the tip of the scalpel," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "As we progress toward an era of personalized medicine -- where patients' own tissues and cells will be re-engineered into replacement organs and treatments -- we will need noninvasive ways to monitor what happens inside the body in real time. This technique fulfills another promise of nanobiology."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. K. Harrington, H. Chahboune, J. M. Criscione, A. Y. Li, N. Hibino, T. Yi, G. A. Villalona, S. Kobsa, D. Meijas, D. R. Duncan, L. Devine, X. Papademetri, T. Shin'oka, T. M. Fahmy, C. K. Breuer. Determining the fate of seeded cells in venous tissue-engineered vascular grafts using serial MRI. The FASEB Journal, 2011; 25 (12): 4150 DOI: 10.1096/fj.11-185140

Cite This Page:

Federation of American Societies for Experimental Biology. "Researchers develop a way to monitor engineered blood vessels as they grow in patients." ScienceDaily. ScienceDaily, 9 December 2011. <www.sciencedaily.com/releases/2011/11/111130120112.htm>.
Federation of American Societies for Experimental Biology. (2011, December 9). Researchers develop a way to monitor engineered blood vessels as they grow in patients. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2011/11/111130120112.htm
Federation of American Societies for Experimental Biology. "Researchers develop a way to monitor engineered blood vessels as they grow in patients." ScienceDaily. www.sciencedaily.com/releases/2011/11/111130120112.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How To: Mixed Green Salad Topped With Camembert Cheese

How To: Mixed Green Salad Topped With Camembert Cheese

Rumble (Jan. 26, 2015) Learn how to make a mixed green salad topped with a pan-seared camembert cheese in only a minute! Music: Courtesy of Audio Network. Video provided by Rumble
Powered by NewsLook.com
Water Fleas Prepare for Space Voyage

Water Fleas Prepare for Space Voyage

Reuters - Innovations Video Online (Jan. 26, 2015) Scientists are preparing a group of water fleas for a unique voyage into space. The aquatic crustaceans, known as Daphnia, can be used as a miniature model for biomedical research, and their reproductive and swimming behaviour will be tested for signs of stress while on board the International Space Station. Jim Drury went to meet the team. Video provided by Reuters
Powered by NewsLook.com
Husky Puppy Plays With Ferret

Husky Puppy Plays With Ferret

Rumble (Jan. 26, 2015) It looks like this 2-month-old Husky puppy and the family ferret are going to be the best of friends. Look at how much fun they&apos;re having together! Credit to &apos;Vira&apos;. Video provided by Rumble
Powered by NewsLook.com
Scientists Model Flying, Walking Drone After Vampire Bats

Scientists Model Flying, Walking Drone After Vampire Bats

Buzz60 (Jan. 26, 2015) Swiss scientists build a new drone that can both fly and walk, modeling it after the movements of common vampire bats. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins