Featured Research

from universities, journals, and other organizations

Smoking is strongly associated with squamous cell carcinoma among women

Date:
December 11, 2011
Source:
H. Lee Moffitt Cancer Center & Research Institute
Summary:
Women who have non-melanoma skin cancers are more likely to have smoked cigarettes compared to women without skin cancer, said researchers.

Women who have non-melanoma skin cancers are more likely to have smoked cigarettes compared to women without skin cancer, said researchers at Moffitt Cancer Center in Tampa, Fla., who published study results in a recent issue of Cancer Causes Control.

The study investigated the relationship between cigarette smoking and non-melanoma skin cancers, including basal cell carcinoma (BCC) and squamous cell carcinomas (SCC). Smoking histories were assessed and compared between patients diagnosed with BCC and/or SCC, and a group of controls composed of patients who were screened for skin cancers, but who were not diagnosed with and had no history of skin cancer.

The study's 698 participants were recruited through Moffitt's Lifetime Screening and Prevention Center and the University of South Florida's Dermatology and Family Medicine Clinics. Participants were asked about their smoking behaviors in terms of years smoked, how many cigarettes per day they smoked, and when those who once smoked quit smoking. The results were stratified by sex.

Study results showed that cigarette smoking was associated with non-melanoma skin cancer overall, and that the risk increased with numbers of cigarettes per day, total years of smoking, and pack-years smoked. Associations were particularly strong for SCC, with SCC being more than two times as likely in those who have smoked for 20 or more years compared to controls.

"Among men, positive associations with smoking of equal magnitude were observed for BCC and SCC, although none of the associations were statistically significant," said Dana E. Rollison, Ph.D., study lead author and an associate member in the Moffitt Department of Cancer Epidemiology. "However, among women, smoking was not associated with BCC, while highly statistically significant associations were observed with SCC. Women with SCC were almost four times more likely than controls to have smoked for 20 or more years."

The researchers concluded that:

  • Cigarette smoking was associated with non-melanoma skin cancer, and the risk increased with increasing dose (cigarettes per day) and number of years smoked.
  • Among men, smoking was modestly associated with BCC andSCC.
  • Among women, smoking was strongly associated with SCC, but not BCC.

Why women smokers should be more likely than men to be diagnosed with SCC is not clear, said the researchers.

"Observations from the lung cancer literature may provide possible explanations for why smoking was a higher risk factor for SCC in women," wrote Rollison and co-authoring colleagues both at Moffitt and across USF's College of Medicine. "Female current smokers have higher lung cancer risks than men. Women have been shown to have more active CYP enzyme activity in the lung, where CYP is responsible for metabolizing 70-80 percent of nicotine. In addition, the up-regulation of CYP by estrogen may play a role."

Also, women have been shown to have higher levels of DNA adducts and lower levels of DNA repair in the lung as compared to men, said Rollison.

"Further study is needed to shed more light on the sex-based differences and the role of smoking in non-melanoma skin cancers," concluded Rollison.


Story Source:

The above story is based on materials provided by H. Lee Moffitt Cancer Center & Research Institute. Note: Materials may be edited for content and length.


Cite This Page:

H. Lee Moffitt Cancer Center & Research Institute. "Smoking is strongly associated with squamous cell carcinoma among women." ScienceDaily. ScienceDaily, 11 December 2011. <www.sciencedaily.com/releases/2011/12/111208173714.htm>.
H. Lee Moffitt Cancer Center & Research Institute. (2011, December 11). Smoking is strongly associated with squamous cell carcinoma among women. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2011/12/111208173714.htm
H. Lee Moffitt Cancer Center & Research Institute. "Smoking is strongly associated with squamous cell carcinoma among women." ScienceDaily. www.sciencedaily.com/releases/2011/12/111208173714.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins