Featured Research

from universities, journals, and other organizations

Origins of blood stem cells detemined

Date:
December 14, 2011
Source:
University of Pennsylvania School of Medicine
Summary:
Scientists have discovered a molecular marker for the immediate precursors of hematopoietic stem cells in the developing embryo, which provides much-needed insights for making these cells from engineered precursors.

A mouse fetus shortly after hematopoietic stem cells appear.
Credit: Nancy Speck, PhD, Perelman School of Medicine, University of Pennsylvania

A research team led by Nancy Speck, PhD, professor of Cell and Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania, has discovered a molecular marker for the immediate precursors of hematopoietic (blood) stem cells (HSCs) in the developing embryo, which provides much-needed insights for making these cells from engineered precursors.

Related Articles


Related Images

Because HSCs, found in the bone marrow of adult mammals, generate all of the blood cell types of the body, unlocking the secrets of their origin may help researchers to better manipulate embryonic stem cells to generate new blood cells for therapy. Speck is also an Investigator with the Abramson Family Cancer Research Institute at Penn. The work was recently published in Cell Stem Cell.

"The ultimate goal for stem-cell therapies is to take precursor stem cells and push them down a particular lineage to replace diseased or dead cells in human adults or children," says Speck. First things first, she says: "You have to understand how this happens in the embryo."

Previous studies indicated that HSCs originated from a small population of cells lining blood vessels, called endothelial cells. But, it was unclear precisely which endothelial cells transitioned to blood stem cells during early development.

In the embryo, there are multiple waves of blood-cell development. The first wave gives the embryo a quick oxygen source and the final wave sets up the development of HSCs that ultimately reside in adult bone marrow. The first wave of progenitors can be generated in the lab from embryonic or induced pluripotent stem cells, but efforts to produce hematopoietic stem cells have failed, says Speck.

"Understanding the developmental origins of hematopoietic stem cells is important for learning how to produce them in the lab from embryonic or induced pluripotent stem cells," says Speck.

How much closer does this study take hematologists to be able to make HSCs successfully? Scientists can make blood cells from endothelial cells now and can monitor these in the embryo. But not all endothelial cells give rise to HSCs. The team used a special marker to follow the development of HSCs. Progenitor cells in the first wave of embryo blood-cell development and the HSCs of later waves of development differentiate from distinct populations of blood-producing endothelial cells. The marker, called Ly6a, is expressedin the endothelial cells that lead to HSCs, and it is not expressed in endothelial cells that make the first wave of blood cells.

Knowing more about the development of HSCs and its distinct markers will be helpful in making HSCs in the lab for stem-cell therapies so leukemia patients, for example -- many of whom are unable to find suitable donors -- could use their own cells to make HSCs and eventually blood cells depleted by blood cancers and some of its treatments.

The work was funded in part by the National Heart, Lung, and Blood Institute.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael J. Chen, Yan Li, Maria Elena De Obaldia, Qi Yang, Amanda D. Yzaguirre, Tomoko Yamada-Inagawa, Chris S. Vink, Avinash Bhandoola, Elaine Dzierzak, Nancy A. Speck. Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells. Cell Stem Cell, 2011; 9 (6): 541 DOI: 10.1016/j.stem.2011.10.003

Cite This Page:

University of Pennsylvania School of Medicine. "Origins of blood stem cells detemined." ScienceDaily. ScienceDaily, 14 December 2011. <www.sciencedaily.com/releases/2011/12/111209105752.htm>.
University of Pennsylvania School of Medicine. (2011, December 14). Origins of blood stem cells detemined. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2011/12/111209105752.htm
University of Pennsylvania School of Medicine. "Origins of blood stem cells detemined." ScienceDaily. www.sciencedaily.com/releases/2011/12/111209105752.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins