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New evidence that bacteria in large intestine have a role in obesity

Date:
January 12, 2012
Source:
American Chemical Society
Summary:
Bacteria living in people's large intestine may slow down the activity of the "good" kind of fat tissue, a special fat that quickly burns calories and may help prevent obesity, scientists are reporting in a new study. The discovery could shed light on ways to prevent obesity and promote weight loss, including possible microbial and pharmaceutical approaches, the authors said.
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Bacteria living in people's large intestine may slow down the activity of the "good" kind of fat tissue, a special fat that quickly burns calories and may help prevent obesity, scientists are reporting in a new study. The discovery, published in ACS' Journal of Proteome Research, could shed light on ways to prevent obesity and promote weight loss, including possible microbial and pharmaceutical approaches, the authors said.

Sandrine P. Claus, Jeremy K. Nicholson and colleagues explain that trillions of bacteria live in the large intestine of healthy people, where they help digest food and make certain vitamins. In recent years, however, scientists have realized that these bacteria do more -- they interact with the rest of the body in ways that affect the use of energy and its storage as fat and finely tune the immune system. Claus and Nicholson decided to see how intestinal bacteria might affect the activity of brown fat. The "good" fat that burns calories quickly before they can be stored as fat, brown fat exists in small deposits in the neck area and elsewhere -- not like "white fat" in flab around the waist and buttocks. No one had checked to see if those bacteria could have an effect on brown fat, the researchers noted.

In experiments that compared "germ-free" (GF) mice, which don't have large-intestine bacteria, and regular mice, the scientists uncovered evidence suggesting that the bacteria do influence the activity of brown fat. Brown fat in the GF mice seemed to be more active, burning calories faster than in regular mice. Large-intestine bacteria also seemed to be linked with gender differences in weight. Normal male mice were heavier and fattier than females, but those differences vanished in the GF mice. The research also uncovered major differences in the interactions between males and females and their intestinal bacteria that might help explain why the obesity epidemic is more serious and rapidly developing in women. Those and other findings may point the way toward approaches that kick-up the activity of brown fat in humans to prevent or treat obesity.

The authors acknowledge funding from Nestlé as part of the Imperial College London-Nestlé strategic alliance.


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The above post is reprinted from materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Renaud Mestdagh, Marc-Emmanuel Dumas, Serge Rezzi, Sunil Kochhar, Elaine Holmes, Sandrine P. Claus, Jeremy K. Nicholson. Gut Microbiota Modulate the Metabolism of Brown Adipose Tissue in Mice. Journal of Proteome Research, 2011; 111121110846007 DOI: 10.1021/pr200938v

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American Chemical Society. "New evidence that bacteria in large intestine have a role in obesity." ScienceDaily. ScienceDaily, 12 January 2012. <www.sciencedaily.com/releases/2011/12/111221105804.htm>.
American Chemical Society. (2012, January 12). New evidence that bacteria in large intestine have a role in obesity. ScienceDaily. Retrieved August 31, 2015 from www.sciencedaily.com/releases/2011/12/111221105804.htm
American Chemical Society. "New evidence that bacteria in large intestine have a role in obesity." ScienceDaily. www.sciencedaily.com/releases/2011/12/111221105804.htm (accessed August 31, 2015).

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