Featured Research

from universities, journals, and other organizations

New evidence that bacteria in large intestine have a role in obesity

Date:
January 12, 2012
Source:
American Chemical Society
Summary:
Bacteria living in people's large intestine may slow down the activity of the "good" kind of fat tissue, a special fat that quickly burns calories and may help prevent obesity, scientists are reporting in a new study. The discovery could shed light on ways to prevent obesity and promote weight loss, including possible microbial and pharmaceutical approaches, the authors said.

Bacteria living in people's large intestine may slow down the activity of the "good" kind of fat tissue, a special fat that quickly burns calories and may help prevent obesity, scientists are reporting in a new study. The discovery, published in ACS' Journal of Proteome Research, could shed light on ways to prevent obesity and promote weight loss, including possible microbial and pharmaceutical approaches, the authors said.

Sandrine P. Claus, Jeremy K. Nicholson and colleagues explain that trillions of bacteria live in the large intestine of healthy people, where they help digest food and make certain vitamins. In recent years, however, scientists have realized that these bacteria do more -- they interact with the rest of the body in ways that affect the use of energy and its storage as fat and finely tune the immune system. Claus and Nicholson decided to see how intestinal bacteria might affect the activity of brown fat. The "good" fat that burns calories quickly before they can be stored as fat, brown fat exists in small deposits in the neck area and elsewhere -- not like "white fat" in flab around the waist and buttocks. No one had checked to see if those bacteria could have an effect on brown fat, the researchers noted.

In experiments that compared "germ-free" (GF) mice, which don't have large-intestine bacteria, and regular mice, the scientists uncovered evidence suggesting that the bacteria do influence the activity of brown fat. Brown fat in the GF mice seemed to be more active, burning calories faster than in regular mice. Large-intestine bacteria also seemed to be linked with gender differences in weight. Normal male mice were heavier and fattier than females, but those differences vanished in the GF mice. The research also uncovered major differences in the interactions between males and females and their intestinal bacteria that might help explain why the obesity epidemic is more serious and rapidly developing in women. Those and other findings may point the way toward approaches that kick-up the activity of brown fat in humans to prevent or treat obesity.

The authors acknowledge funding from Nestlι as part of the Imperial College London-Nestlι strategic alliance.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Renaud Mestdagh, Marc-Emmanuel Dumas, Serge Rezzi, Sunil Kochhar, Elaine Holmes, Sandrine P. Claus, Jeremy K. Nicholson. Gut Microbiota Modulate the Metabolism of Brown Adipose Tissue in Mice. Journal of Proteome Research, 2011; 111121110846007 DOI: 10.1021/pr200938v

Cite This Page:

American Chemical Society. "New evidence that bacteria in large intestine have a role in obesity." ScienceDaily. ScienceDaily, 12 January 2012. <www.sciencedaily.com/releases/2011/12/111221105804.htm>.
American Chemical Society. (2012, January 12). New evidence that bacteria in large intestine have a role in obesity. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2011/12/111221105804.htm
American Chemical Society. "New evidence that bacteria in large intestine have a role in obesity." ScienceDaily. www.sciencedaily.com/releases/2011/12/111221105804.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) — Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) — State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) — The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) — CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins