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Hydrogen sulfide reduces glucose-induced injury in kidney cells

Date:
January 4, 2012
Source:
University of Texas Health Science Center at San Antonio
Summary:
Hydrogen sulfide, a noxious gas that smells like rotten eggs, may have beneficial effects in the kidney. Researchers found that this gas diminishes high glucose-induced production of scarring proteins in kidney cells. Considerable work remains to be done before studies can move to animal models.

Hydrogen sulfide, a gas notorious for its rotten-egg smell, may have redeeming qualities after all. It reduces high glucose-induced production of scarring proteins in kidney cells, researchers from The University of Texas Health Science Center San Antonio report in the Journal of Biological Chemistry.

The paper is scheduled for print publication in early 2012.

"There is interest in gases being mediators of biological events," said B.S. Kasinath, M.D., professor of medicine and a nephrologist with UT Medicine San Antonio, the clinical practice of the School of Medicine at the UT Health Science Center. "We found that when we added sodium hydrosulfide, a substance that releases hydrogen sulfide, to kidney cells exposed to high glucose, it decreased the manufacture of matrix proteins that scar the kidney." Consistent with this finding, enzymes in the kidney that facilitate production of hydrogen sulfide were reduced in mice with type 1 or type 2 diabetes, Dr. Kasinath and his team reported.

Scarring in the kidney, called renal fibrosis, is a core defect leading to end-stage kidney disease. Nearly half of end-stage kidney disease in the U.S. is related to diabetes, which is a disease marked by poor regulation of blood glucose.

"We have found a way to decrease matrix protein synthesis, which is a problem in diabetes," Dr. Kasinath said. Because the studies are limited to cells, the finding should not be extrapolated to the treatment of human diabetic kidney disease, he emphasized.

The finding paves the way for studies in mice or other animal models. Both the safety and effectiveness of hydrogen sulfide should be established in animal models of kidney disease before human trials can be considered. This precaution is required because hydrogen sulfide, at higher concentrations, is known to be a toxic agent.

Journal of Biological Chemistry editors selected the team's manuscript to be the Paper of the Week, reserved for the top 1 percent of manuscripts in significance and overall importance. About 50 to 100 papers are selected for this recognition from the more than 6,600 the journal publishes each year.

Hak Joo Lee, Ph.D., a postdoctoral fellow in the Division of Nephrology, is the lead author on the study. Dr. Kasinath, also a member of the Barshop Institute for Longevity and Aging Studies at the Health Science Center, is the senior author and wishes to acknowledge the contributions of his co-authors.

This work was supported by a grant from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases, (DK077295), and a U.S. Department of Veterans Affairs research grant to Dr. Kasinath, the principal investigator.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. J. Lee, M. M. Mariappan, D. Feliers, R. C. Cavaglieri, K. Sataranatarajan, H. E. Abboud, G. Ghosh Choudhury, B. S. Kasinath. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. Journal of Biological Chemistry, 2011; DOI: 10.1074/jbc.M111.278325

Cite This Page:

University of Texas Health Science Center at San Antonio. "Hydrogen sulfide reduces glucose-induced injury in kidney cells." ScienceDaily. ScienceDaily, 4 January 2012. <www.sciencedaily.com/releases/2012/01/120103165039.htm>.
University of Texas Health Science Center at San Antonio. (2012, January 4). Hydrogen sulfide reduces glucose-induced injury in kidney cells. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2012/01/120103165039.htm
University of Texas Health Science Center at San Antonio. "Hydrogen sulfide reduces glucose-induced injury in kidney cells." ScienceDaily. www.sciencedaily.com/releases/2012/01/120103165039.htm (accessed October 22, 2014).

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