Featured Research

from universities, journals, and other organizations

Cell signaling key to stopping growth and migration of brain cancer cells

Date:
January 24, 2012
Source:
University of Colorado Denver
Summary:
Inhibition of cell signaling through the Mer receptor tyrosine kinase pathway shown to both sensitize glioblastoma cells to chemotherapy and decrease their ability to migrate to other, non-targeted areas of the brain.

Brain cancer is hard to treat: it's not only strong enough to resist most chemotherapies, but also nimble enough to migrate away from radiation or surgery to regrow elsewhere.

Related Articles


New research at the University of Colorado Cancer Center shows how to stop both.

Specifically, cells signal themselves to survive, grow, reproduce, and migrate. Two years ago, researchers at the CU Cancer Center showed that turning off a family of signals made brain cancer cells less robust -- it sensitized these previously resistant cells to chemotherapy.

But the second major problem -- migration -- potentially remained.

"I thought, aha, I have this great way to treat this cancer, but needed to check that we weren't going to cause other problems. We wondered if turning off TAM family signaling would make brain cancer cells crawl away to a new spot where they might make new problems," says Amy Keating, MD, investigator at the CU Cancer Center and senior author of the study, recently published in the journal Nature: Oncogene.

So Keating and colleagues went inside this TAM signaling family to explore how its members affect not only proliferation but migration. When they inhibited signaling through the other family member Axl, little changed (actually this was good: at least turning off this signaling pathway didn't promote cancer cell migration).

But when Keating and colleagues turned off signaling through the Mer pathway, it was neither too hot nor too cold -- it was just right, and these affected cancer cells were not only more sensitive to chemotherapy, but also unable to escape to safer areas of the brain.

Currently glioblastoma multiforme affects 45,000 people in the United States every year, the majority of whom will not survive 14 months after diagnosis.

"This represents a new targeted therapy, offering a potential new direction that nobody's tried before," says Keating, assistant professor of pediatrics at the University of Colorado School of Medicine.

After these extremely promising results with cell lines, Keating and colleagues are currently testing the technology in mice, after which all involved hope to move soon to human clinical trials.

Amy Keating is generously supported by the St Baldrick's Foundation and the NIH K12 HD068372Child Health Research Career Development Award.


Story Source:

The above story is based on materials provided by University of Colorado Denver. The original article was written by Garth Sundem. Note: Materials may be edited for content and length.


Journal Reference:

  1. A E J Rogers, J P Le, S Sather, B M Pernu, D K Graham, A M Pierce, A K Keating. Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology. Oncogene, 2011; DOI: 10.1038/onc.2011.588

Cite This Page:

University of Colorado Denver. "Cell signaling key to stopping growth and migration of brain cancer cells." ScienceDaily. ScienceDaily, 24 January 2012. <www.sciencedaily.com/releases/2012/01/120118111530.htm>.
University of Colorado Denver. (2012, January 24). Cell signaling key to stopping growth and migration of brain cancer cells. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2012/01/120118111530.htm
University of Colorado Denver. "Cell signaling key to stopping growth and migration of brain cancer cells." ScienceDaily. www.sciencedaily.com/releases/2012/01/120118111530.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins