Featured Research

from universities, journals, and other organizations

Researchers engineer a switch to tame aggressive cancers

Date:
January 23, 2012
Source:
Lawson Health Research Institute
Summary:
A new imaging platform provides insight into the exact moment when cancer cells turn deadly. The new approach can modulate and monitor how the effects of a particular protein can affect the entire tumor in real-time.

When cancers become aggressive and spread they are the most deadly. Unfortunately, little is known about how to stop this development. A new imaging platform developed by Lawson Health Research Institute's Drs. Ann Chambers and John Lewis is providing insight into just that -- the exact moment when cancer cells turn deadly.

Related Articles


Certain proteins, such as E-cadherin, are important for the maintenance of normal tissue structure. When tumors become more aggressive, they often lose E-cadherin, resulting in dramatic changes to their structure, function and ability to spread. But when cancer cells are forced to express E-cadherin, research suggests they behave less aggressively and revert back to normal. Unfortunately, limitations in our ability to directly monitor these effects have made it difficult for scientists to assess the full impact.

In a new study in PLoS ONE, Drs. Chambers and Lewis reveal a new imaging platform that can modulate and monitor how the effects of a particular protein can affect the entire tumor in real-time. The approach uses a shell-less chick embryo model implanted with human cancer cells. "This accessible set-up allows us to introduce E-cadherin directly into the tumor environment, where it has immediate and dramatic effects," says Dr. Hon Leong, the lead author of this study. "Using 3D time-lapse imaging, the impact of this protein can be visualized and the subsequent effects on cancer cell structure, function and aggressiveness can be monitored in real time for up to 48 hours."

Drs. Chambers and Lewis hope this approach will allow scientists to determine how proteins like E-cadherin can exert their tumor-suppressive properties on the deadly spread of cancer. Through further research, they believe their approach could provide valuable information to help moderate aggressive cancers and improve patient outcomes.

"The insights afforded by this technology will help scientists revisit other proteins thought to be important in metastatic spread, but whose modes of action are not understood, and to watch how they actually function in real-time," says Dr. Chambers.

"Although genomics technology has revealed many new proteins that could force cancers to 'switch' back to their less aggressive state, these new targets have not yet been validated in preclinical models like mice because it is difficult to determine the molecular effects on each individual cancer cell," Dr. Lewis says. "This novel platform allows us to produce compelling photographic evidence of how these anti-cancer proteins work and gain insight into their mechanisms."


Story Source:

The above story is based on materials provided by Lawson Health Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hon S. Leong, Michael M. Lizardo, Amber Ablack, Victor A. McPherson, Thomas J. Wandless, Ann F. Chambers, John D. Lewis. Imaging the Impact of Chemically Inducible Proteins on Cellular Dynamics In Vivo. PLoS ONE, 2012; 7 (1): e30177 DOI: 10.1371/journal.pone.0030177

Cite This Page:

Lawson Health Research Institute. "Researchers engineer a switch to tame aggressive cancers." ScienceDaily. ScienceDaily, 23 January 2012. <www.sciencedaily.com/releases/2012/01/120120010355.htm>.
Lawson Health Research Institute. (2012, January 23). Researchers engineer a switch to tame aggressive cancers. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2012/01/120120010355.htm
Lawson Health Research Institute. "Researchers engineer a switch to tame aggressive cancers." ScienceDaily. www.sciencedaily.com/releases/2012/01/120120010355.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mom Triumphs Over Tragedy, Helps Other Families

Mom Triumphs Over Tragedy, Helps Other Families

AP (Mar. 3, 2015) After her son, Dax, died from a rare form of leukemia, Julie Locke decided to give back to the doctors at St. Jude Children&apos;s Research Hospital who tried to save his life. She raised $1.6M to help other patients and their families. (March 3) Video provided by AP
Powered by NewsLook.com
Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

AFP (Mar. 3, 2015) Thick black puddles and a looted, leaking ruin are all that remain of the Thar Jath oil treatment facility, once a crucial part of South Sudan&apos;s mainstay industry. Duration: 01:13 Video provided by AFP
Powered by NewsLook.com
Woman Convicted of Poisoning Son

Woman Convicted of Poisoning Son

AP (Mar. 3, 2015) A woman who blogged for years about her son&apos;s constant health woes was convicted Monday of poisoning him to death by force-feeding heavy concentrations of sodium through his stomach tube. (March 3) Video provided by AP
Powered by NewsLook.com
Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins