Featured Research

from universities, journals, and other organizations

Therapeutically useful stem cell derivatives in need of stability

Date:
January 24, 2012
Source:
Journal of Clinical Investigation
Summary:
Human stem cells capable of giving rise to any fetal or adult cell type are known as pluripotent stem cells. It is hoped that human embryonic stem cells can be used to generate cell populations with therapeutic utility. In this context, neural derivatives of hESCs are being tested in clinical trials. However, researchers in France have now generated cautionary data that suggest that additional quality controls need to be put in place to ensure that neural derivatives of hESCs are not genomically unstable, a common characteristic of cancer cells.

Human stem cells capable of giving rise to any fetal or adult cell type are known as pluripotent stem cells. It is hoped that such cells, the most well known being human embryonic stem cells (hESCs), can be used to generate cell populations with therapeutic utility. In this context, neural derivatives of hESCs are being tested in clinical trials.

However, Natalie Lefort and colleagues, at the Institute for Stem cell Therapy and Exploration of Monogenic diseases, France, have now generated cautionary data that suggest that additional quality controls need to be put in place to ensure that neural derivatives of human pluripotent stem cells are not genomically unstable, a common characteristic of cancer cells.

The research appears in the Journal of Clinical Investigation.

The key observation of Lefort and colleagues was that neural derivatives of human pluripotent stem cells frequently acquire extra material from chromosome 1q. Worryingly, this chromosomal defect has been associated with some blood cell cancers and pediatric brain tumors with poor clinical outcome, although Lefort and colleagues found that the abnormal neural cells they detected were unable to form tumors in mice.

As noted by Neil Harrison, at the University of Sheffield, United Kingdom, in an accompanying commentary, while the data raise safety issues relevant for the therapeutic use of these cells, the fact that the same chromosome was affected in all cases suggests that it should be possible to design screening strategies to detect and remove these cells.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Christine Varela, Jérôme Alexandre Denis, Jérôme Polentes, Maxime Feyeux, Sophie Aubert, Benoite Champon, Geneviève Piétu, Marc Peschanski, Nathalie Lefort. Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells. Journal of Clinical Investigation, 2012; DOI: 10.1172/JCI46268
  2. Neil J. Harrison. Genetic instability in neural stem cells: an inconvenient truth? Journal of Clinical Investigation, 2012; DOI: 10.1172/JCI62002

Cite This Page:

Journal of Clinical Investigation. "Therapeutically useful stem cell derivatives in need of stability." ScienceDaily. ScienceDaily, 24 January 2012. <www.sciencedaily.com/releases/2012/01/120124140315.htm>.
Journal of Clinical Investigation. (2012, January 24). Therapeutically useful stem cell derivatives in need of stability. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2012/01/120124140315.htm
Journal of Clinical Investigation. "Therapeutically useful stem cell derivatives in need of stability." ScienceDaily. www.sciencedaily.com/releases/2012/01/120124140315.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) — Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) — Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins