Featured Research

from universities, journals, and other organizations

Oral cancer expert finds unexpected treatment breakthrough from raspberries and old breast cancer therapy

Date:
January 27, 2012
Source:
Ohio State University Center for Clinical and Translational Science
Summary:
A dentistry professor has dedicated her nearly 30-year career to studying new strategies to preventing oral cancer. Her efforts have helped create a cancer-fighting mouthwash derived from black raspberries and an adhesive patch that delivers targeted therapy to pre-cancerous lesions in the mouth - possibly sparing patients from repeat surgeries.

Dr. Susan Mallery, a professor in the College of Dentistry at The Ohio State University and Oral Pathology Consultant at the Ohio State University and James Cancer hospitals, has dedicated her nearly 30-year career to studying new strategies to preventing oral cancer. Oral cancer is currently responsible for more than 7,000 deaths each year, and has a particularly high mortality rate. Treatment relies on excising cells before they turn cancerous, but as many as one-third of all patients will experience a recurrence within a year.

"While not all oral lesions progress to cancer, we cannot accurately predict which will be the 'bad actors.' This often results in multiple surgeries and high anxiety in both our patients and clinicians," says Mallery.

Since 2003, Mallery has been investigating a variety of agents ranging from anti-angiogenesis drugs to natural products, to identify new therapeutics that can suppress the conversion of pre-cancerous to cancerous cells. Her first breakthrough was the creation of an oral gel based on anthocyanins, powerful antioxidants found in black raspberries. Study results showed that the gel, when applied to the mouth, would suppress genes associated with functions that allow cancerous cells to grow, thus diminishing the risk for recurring lesions.

Mallery next turned her attention to identifying alternatives to the surgical removal of pre-cancerous lesions. Mallery thought she might have good possibilities with fenretinide, a decades-old breast cancer treatment that had been largely abandoned by oral pathologists despite strong clinical evidence that showed fenretinide can induce cell death, encourage the body's natural cellular defense system and strangle blood supply to tumors.

"The discrepancy between the established efficacy of fenretinide in other cancer types and in oral cancer was puzzling. Then it occurred to me that maybe the structure of the oral mucosa wasn't allowing a therapeutic amount to reach the lesions, even at high doses," says Mallery. "We knew we needed to come up with a way to deliver the therapy directly to the lesion"

In 2009, The Ohio State University College of Dentistry, in collaboration with the Center for Clinical and Translational Science (CCTS) awarded Mallery and her team funding for a project aimed at developing a way to treat precancerous lesions directly in the mouth and preventing recurring lesions.

Mallery partnered with two pharmaceutical chemists from the University of Michigan (Drs. Stephen Schwendeman and Kashappa Goud Desai) along with two Ohio State investigators Drs. Gary Stoner and Peter Larsen to develop a first of its kind patch that could stick to the inside of the mouth, and deliver a continuous therapeutic dose of fenretinide directly on the lesion.

The research team plans to move the patch into pre-clinical and clinical trials, and is already looking at a combination of fenretinide and anthocyanins, as well as testing a combination therapy using the patch and black raspberry-based gel mouthwash to prevent recurrence of lesions.

"If we can effectively treat the lesions with the patch, and then prevent more from coming back, we will completely change -- and improve upon -- the way oral cancer is currently treated," said Mallery.

Mallery says the best course of action is to prevent oral cancer in the first place, and provides the following tips:

  • Use of tobacco products -- particularly burned tobacco -- is the greatest risk factor for development of oral cancer.
  • Watch what you drink and eat. Alcohol consumption -- in excess and especially during smoking -- can have an additive effect and increase your chances to develop oral cancer. Conversely, a diet high in fruits and vegetables can lower your risk.
  • Infection with human papilloma viruses (HPV) causes a subset of oral cancers. Inoculation of both young women and men with the HPV vaccine would markedly decrease HPV-associated oral cancers.
  • Remember the mouth heals quickly. If you have a sore in your mouth that doesn't heal in 14 days, seek prompt treatment from your dentist.
  • See your dentist at least once a year (better if twice a year) for a complete oral health screening. This is extremely important as oral cancer initially develops a precancerous oral lesions (patient treatment and survival is much better at this stage).

Story Source:

The above story is based on materials provided by Ohio State University Center for Clinical and Translational Science. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University Center for Clinical and Translational Science. "Oral cancer expert finds unexpected treatment breakthrough from raspberries and old breast cancer therapy." ScienceDaily. ScienceDaily, 27 January 2012. <www.sciencedaily.com/releases/2012/01/120127135715.htm>.
Ohio State University Center for Clinical and Translational Science. (2012, January 27). Oral cancer expert finds unexpected treatment breakthrough from raspberries and old breast cancer therapy. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2012/01/120127135715.htm
Ohio State University Center for Clinical and Translational Science. "Oral cancer expert finds unexpected treatment breakthrough from raspberries and old breast cancer therapy." ScienceDaily. www.sciencedaily.com/releases/2012/01/120127135715.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins