Featured Research

from universities, journals, and other organizations

Discovery of new vaccine approach for treatment of cancer

Date:
January 28, 2012
Source:
Trinity College Dublin
Summary:
Scientists have developed a new vaccine to treat cancer at the pre-clinical level. They developed a new approach for treating the disease based on manipulating the immune response to malignant tumors.

Scientists in Trinity College Dublin, Ireland, have developed a new vaccine to treat cancer at the pre-clinical level. The research team led by Professor Kingston Mills, Professor of Experimental Immunology at Trinity College Dublin discovered a new approach for treating the disease based on manipulating the immune response to malignant tumours. The discovery has been patented and there are plans to develop the vaccine for clinical use for cancer patients.

Related Articles


The first cancer vaccine Sipuleucel-T (Provenge™) was licensed last year for use in prostate cancer patients unresponsive to hormone treatment. Unfortunately, this cell based vaccine only improves patient survival by an average of 4.1 months. Vaccines for infectious diseases are highly effective at generating immune responses that prevent infection with bacteria or viruses. The immune system can also protect us against tumours and in theory a vaccine approach should be effective against cancer. In practice this has proven very difficult because unlike infectious diseases, tumours are derived from normal human cells, and not made up of foreign substances or antigens capable of triggering an immune response. The tumours instead produce molecules that suppress the efficacy of the immune system. They generate regulatory cells that inhibit the immune response that could potentially clear the tumours.

Professor Mills' group has developed a novel vaccine and immunotherapeutic approach that can overcome these obstacles and has the potential to significantly improve on existing technologies.

The therapy is based on a combination of molecules that manipulates the immune response to curb the regulatory arm while enhancing the protective arm, allowing the induction of specialist white blood cell called killer T cells to target and eliminate the tumours. The new vaccine approach was found to be highly effective at pre-clinical stage in treating a range of cancers in murine models.

The research was performed by a Senior Postdoctoral Fellow Dr Neil Marshall, at Trinity College Dublin, with the help of two PhD students, Anna-Maria Corcoran and Karen Galvin and was funded by a Science Foundation Ireland Principal Investigator award to Professor Mills. The discoveries have been patent protected and Professor Mills has plans to translate them to the clinic via a TCD Campus Company, TriMod Therapeutics that he co-founded with Dr Jeremy Skillington.


Story Source:

The above story is based on materials provided by Trinity College Dublin. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. A. Marshall, K. C. Galvin, A.-M. B. Corcoran, L. Boon, R. Higgs, K. H. G. Mills. Immunotherapy with PI3K Inhibitor and Toll-Like Receptor Agonist Induces IFN- IL-17 Polyfunctional T Cells That Mediate Rejection of Murine Tumors. Cancer Research, 2011; DOI: 10.1158/0008-5472.CAN-11-0307

Cite This Page:

Trinity College Dublin. "Discovery of new vaccine approach for treatment of cancer." ScienceDaily. ScienceDaily, 28 January 2012. <www.sciencedaily.com/releases/2012/01/120127140526.htm>.
Trinity College Dublin. (2012, January 28). Discovery of new vaccine approach for treatment of cancer. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2012/01/120127140526.htm
Trinity College Dublin. "Discovery of new vaccine approach for treatment of cancer." ScienceDaily. www.sciencedaily.com/releases/2012/01/120127140526.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins