Featured Research

from universities, journals, and other organizations

Experimental drug reduces 'second stroke' after aneurysm rupture

Date:
February 1, 2012
Source:
American Heart Association
Summary:
An experimental drug, clazosentan, reduced the risk of blood vessel spasm in patients with a brain aneurysm, according to new research.

An experimental drug, clazosentan, reduced the risk of blood vessel spasm in patients with a brain aneurysm, according to research presented at the American Stroke Association's International Stroke Conference 2012.

Related Articles


In patients with a subarachnoid hemorrhage, even after the burst weak spot in the vessel is closed, irritation from the initial bleeding can cause blood vessels to constrict, cutting off normal blood supply and resulting in even more brain damage. This is often called a "second stroke." The vessel constriction is called angiographic vasospasm (VSP), which can occur about three to 14 days after aneurysm rupture.

"We don't have very effective treatments for this complication," said R. Loch Macdonald, M.D., study lead author and head of neurosurgery at St. Michael's Hospital, University of Toronto in Ontario, Canada. "The treatment in use now is very expensive and risky and doesn't work very well, and about half of the patients suffer permanent problems from it."

The Effect of Clazosentan on Clinical Outcome after Aneurysmal Subarachnoid Hemorrhage and Endovascular Coiling (CONSCIOUS-3) Study included 571 patients with a ruptured aneurysm treated with an endovascular coil, a device used to repair the ruptured blood vessel.

Researchers divided patients into three groups, each given either a placebo, 5 mg clazosentan or 15 mg clazosentan. They halted CONSCIOUS-3 prematurely after patients in CONSCIOUS-2 (a trial of patients whose ruptured aneurysm was secured by coiling), which ran simultaneously, showed no benefit from the drug.

In CONSCIOUS-3, 27 percent of patients on placebo died, had vasospasm-related blood clots or neurological problems, or had rescue therapy to treat vasospasm, compared with 24 percent in the 5 mg/h and 15 percent in the 15 mg/h clazosentan groups. The odds of this combined endpoint were 53 percent lower at the higher clazosentan dose than with a placebo.

"Despite having less than half of the intended patients in the study, we were encouraged to see that at a high dose there was a significant reduction in vasospasm in patients initially treated with endovascular coiling," Macdonald said.

In other findings:

  • Neurological deficits decreased with increasing clazosentan dose.
  • Rescue therapy was three times less in patients with 15 mg/h clazosentan (7 percent) compared to those receiving placebo (21 percent).
  • The occurrence of poor functional outcome or deaths within 12 weeks was not significantly different between placebo and medication groups.
  • Patients receiving clazosentan had more lung complications, anemia and low blood pressure than those on placebo.

"The data suggests that the drug is effective at reducing delayed cerebral ischemia, its side effect profile is acceptable, and further studies with different doses, administration regimens, and the avoidance of other vasodilators may allow an improvement in outcome to be demonstrated," Macdonald said.

Co-authors are: Randall Higashida, M.D.; Emanuela Keller, M.D.; Stephan A. Mayer, M.D.; Andrew J. Molyneux, M.D.; Andreas Raabe, M.D.; Peter Vajkoczy, M.D.; Isabel Wanke, M.D.; Doris Bach, M.Sc.; Aline Frey, Pharm.D.; Pegah Nowbakht, Ph.D.; Sιbastien Roux, M.D.; and Neal F. Kassell, M.D.

Actelion Pharmaceuticals funded the study.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Experimental drug reduces 'second stroke' after aneurysm rupture." ScienceDaily. ScienceDaily, 1 February 2012. <www.sciencedaily.com/releases/2012/02/120201094319.htm>.
American Heart Association. (2012, February 1). Experimental drug reduces 'second stroke' after aneurysm rupture. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2012/02/120201094319.htm
American Heart Association. "Experimental drug reduces 'second stroke' after aneurysm rupture." ScienceDaily. www.sciencedaily.com/releases/2012/02/120201094319.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins