Featured Research

from universities, journals, and other organizations

Largest-ever gene study of Type 2 diabetes finds variants across many ethnic groups

Date:
February 9, 2012
Source:
Children's Hospital of Philadelphia
Summary:
The largest genetics study to date of Type 2 diabetes has identified new gene variants associated with risk for the common metabolic disease. An international scientific consortium, studying multi-ethnic populations, uncovered genes that may point to biological targets for developing more effective drugs for T2D.

The largest genetics study to date of type 2 diabetes (T2D) has identified new gene variants associated with risk for the common metabolic disease. An international scientific consortium, studying multiethnic populations, uncovered genes that may point to biological targets for developing more effective drugs for T2D.

Multiple genes and environmental factors interact with T2D, which affects nearly 300 million people worldwide. The majority of the gene variants remain undiscovered.

Study identifies gene variants among multiple ethnic groups

"Scientists have identified only about 10 percent of the genetic variants contributing to T2D, and most previous studies have been based on people of European ancestry," said senior co-author Brendan J. Keating, PhD, of the Center for Applied Genomics at The Children's Hospital of Philadelphia. This international study found that many gene variants associated with T2D overlap across multiple ethnic groups." The current study included subjects with African-American, Hispanic, Asian and European ancestry.

The study appeared online recently in the American Journal of Human Genetics. The study's other senior co-author was Richa Saxena, PhD, from Massachusetts General Hospital and Harvard Medical School.

The research consortium performed a meta-analysis of 39 existing studies of multiethnic populations, comprising over 17,000 cases of individuals with T2D, compared to 70,000 control subjects. This large-scale genetic screening used a customized gene analysis tool to examine 50,000 genetic variants across 2,100 genes known to be associated with cardiovascular and metabolic functions.

The researchers identified variants in four previously unknown genes associated with T2D, discovered six new independent genetic signals in known T2D genes, and verified 16 previously reported T2D-linked variants. A total of nearly 40 gene variants have now been found to raise or lower the risk of T2D. Keating says the current study's genome-wide screening approach in large multi-ethnic samples should be effective in discovering additional diabetes gene variants relevant to multiple ethnic populations.

About Type 2 diabetes

Type 2 diabetes, previously called non-insulin dependent diabetes or adult-onset diabetes, accounts for 90 to 95 percent of all diabetes. It is a chronic metabolic disease in which the body produces insufficient insulin or becomes unable to properly process insulin it does produce. While the risk of T2D generally rises with age, the disorder has been significantly increasing among children and adolescents.

"As we continue to identify more genes associated with type 2 diabetes, we expect that further investigation of their specific biological functions will guide researchers toward new therapies for preventing and treating this disease," said Keating.

The two main groups funding this study were the National Heart, Lung and Blood Institute of the National Institutes of Health through the Candidate Gene Association Resource (CARe) study and the British Heart Foundation. Many other funding sources supported the 39 studies contributing data to this meta-analysis. Among other senior investigators from The Children's Hospital of Philadelphia were Hakon Hakonarson, MD, PhD, director of the Center for Applied Genomics, and Struan F.A. Grant, PhD, associate director of that center.


Story Source:

The above story is based on materials provided by Children's Hospital of Philadelphia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Richa Saxena et al. Large-Scale Gene-Centric Meta-Analysis across 39 studies Identifies Type 2 Diabetes Loci. The American Journal of Human Genetics, 2012; DOI: 10.1016/j.ajhg.2011.12.022

Cite This Page:

Children's Hospital of Philadelphia. "Largest-ever gene study of Type 2 diabetes finds variants across many ethnic groups." ScienceDaily. ScienceDaily, 9 February 2012. <www.sciencedaily.com/releases/2012/02/120209135054.htm>.
Children's Hospital of Philadelphia. (2012, February 9). Largest-ever gene study of Type 2 diabetes finds variants across many ethnic groups. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2012/02/120209135054.htm
Children's Hospital of Philadelphia. "Largest-ever gene study of Type 2 diabetes finds variants across many ethnic groups." ScienceDaily. www.sciencedaily.com/releases/2012/02/120209135054.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Reasons Why Teen Birth Rates Are At An All-Time Low

Reasons Why Teen Birth Rates Are At An All-Time Low

Newsy (Aug. 20, 2014) A CDC report says birth rates among teenagers have been declining for decades, reaching a new low in 2013. We look at several popular explanations. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins