Featured Research

from universities, journals, and other organizations

Microneedle vaccine patch boosts flu protection through robust skin cell immune response

Date:
March 6, 2012
Source:
Emory University
Summary:
Recent research found that microneedle vaccine patches are more effective at delivering protection against influenza virus in mice than subcutaneous or intramuscular inoculation. A new, detailed analysis of the early immune responses helps explain why the skin is such fertile ground for vaccination with these tiny, virtually painless microneedles.

Microneedle patch.
Credit: Image courtesy of Emory University

Recent research found that microneedle vaccine patches are more effective at delivering protection against influenza virus in mice than subcutaneous or intramuscular inoculation. A new, detailed analysis of the early immune responses by the Emory and Georgia Tech research team helps explain why the skin is such fertile ground for vaccination with these tiny, virtually painless microneedles.

Related Articles


The research was published was recently published in the online journal MBio.

The skin, in contrast to the muscles, contains a rich network of antigen-presenting cells, which are immune signaling cells that are essential to initiating an immune response. The researchers found that microneedle skin immunization with inactivated influenza virus resulted in a local increase of cytokines important for recruitment of neutrophils, monocytes and dendritic cells at the site of immunization. All these cells play a role in activating a strong innate immune response against the virus.

Microneedle vaccination also may lead to prolonged depositing of antigen -- the viral molecules that are the targets of antibody responses. Such a prolonged antigen release could allow more efficient uptake by antigen-presenting cells. In addition, activated and matured dendritic cells carrying influenza antigen were found to migrate from the skin- an important feature of activating the adaptive immune response.

The research was led by first author Maria del Pilar Martin, PhD and Richard W. Compans, PhD, Emory professor of microbiology and immunology. Other authors included William C. Weldon, Dimitrios G. Koutsonanos, Hamed Akbari, Ioanna Skountzou, and Joshy Jacob from Emory University and Vladimir G. Zarnitsyn and Mark R. Prausnitz from Georgia Tech.

"Our research reveals new details of the complex but efficient immune response to influenza virus provided by microneedle skin patches," says Compans. "Despite the success of vaccination against influenza, the virus has many subtypes, mutates rapidly and continues to elude complete and long-term protection, and therefore requires annual vaccination with an updated vaccine each year.

"New vaccine formulations and delivery methods such as vaccine-coated microneedle patches could provide an improved protective response, which would be of particular benefit to those at high risk of related complications.

Vaccine delivery to the skin by microneedles is painless, and offers other advantages such as eliminating potential risks due to use of hypodermic needles."

The studies were supported by grants from the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Biomedical Imaging and Bioengineering, which are part of the National Institutes of Health. Dr. Martin was supported by a fellowship from the Emory/UGA Influenza Pathogenesis and Immunology Research Center, a NIAID Center of Excellence for Influenza Research and Surveillance.


Story Source:

The above story is based on materials provided by Emory University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maria del Pilar Martin, William C. Weldon, Vladimir G. Zarnitsyn, Dimitrios G. Koutsonanos, Hamed Akbari, Ioanna Skountzou, Joshy Jacob, Mark R. Prausnitz, and Richard W. Compans. Local Response to Microneedle-Based Influenza Immunization in the Skin. mBio, March/April 2012 DOI: 10.1128/mBio.00012-12

Cite This Page:

Emory University. "Microneedle vaccine patch boosts flu protection through robust skin cell immune response." ScienceDaily. ScienceDaily, 6 March 2012. <www.sciencedaily.com/releases/2012/03/120306073011.htm>.
Emory University. (2012, March 6). Microneedle vaccine patch boosts flu protection through robust skin cell immune response. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2012/03/120306073011.htm
Emory University. "Microneedle vaccine patch boosts flu protection through robust skin cell immune response." ScienceDaily. www.sciencedaily.com/releases/2012/03/120306073011.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins