Featured Research

from universities, journals, and other organizations

Nanomanufacturing using DNA origami

Date:
March 7, 2012
Source:
National Institute of Standards and Technology (NIST)
Summary:
In recent years, scientists have begun to harness DNA's powerful molecular machinery to build artificial structures at the nanoscale using the natural ability of pairs of DNA molecules to assemble into complex structures. While most researchers of "DNA origami" are working to demonstrate what's possible, scientists are now seeking to determine what's practical.

NIST researchers made three DNA origami templates designed so that quantum dots would arrange themselves: (a in the corners, b) diagonally (three dots), and (c in a line (four dots). The researchers found that putting the quantum dots closer together caused them to interfere with one another, leading to higher error rates and lower bonding strength.
Credit: Ko/NIST

In recent years, scientists have begun to harness DNA's powerful molecular machinery to build artificial structures at the nanoscale using the natural ability of pairs of DNA molecules to assemble into complex structures. Such "DNA origami," first developed at the California Institute of Technology, could provide a means of assembling complex nanostructures such as semiconductor devices, sensors and drug delivery systems, from the bottom up.

While most researchers in the field are working to demonstrate what's possible, scientists at the National Institute of Standards and Technology (NIST) are seeking to determine what's practical.

According to NIST researcher Alex Liddle, it's a lot like building with LEGOs -- some patterns enable the blocks to fit together snugly and stick together strongly and some don't.

"If the technology is actually going to be useful, you have to figure out how well it works," says Liddle. "We have determined what a number of the critical factors are for the specific case of assembling nanostructures using a DNA-origami template and have shown how proper design of the desired nanostructures is essential to achieving good yield, moving, we hope, the technology a step forward."

In DNA origami, researchers lay down a long thread of DNA and attach "staples" composed of complementary strands that bind to make the DNA fold up into various shapes, including rectangles, squares and triangles. The shapes serve as a template onto which nanoscale objects such as nanoparticles and quantum dots can be attached using strings of linker molecules.

The NIST researchers measured how quickly nanoscale structures can be assembled using this technique, how precise the assembly process is, how closely they can be spaced, and the strength of the bonds between the nanoparticles and the DNA origami template.

What they found is that a simple structure, four quantum dots at the corners of a 70-nanometer by 100-nanometer origami rectangle, takes up to 24 hours to self-assemble with an error rate of about 5 percent.

Other patterns that placed three and four dots in a line through the middle of the origami template were increasingly error prone. Sheathing the dots in biomaterials, a necessity for attaching them to the template, increases their effective diameter. A wider effective diameter (about 20 nanometers) limits how closely the dots can be positioned and also increases their tendency to interfere with one another during self-assembly, leading to higher error rates and lower bonding strength. This trend was especially pronounced for the four-dot patterns.

"Overall, we think that this process is good for building structures for biological applications like sensors and drug delivery, but it might be a bit of a stretch when applied to semiconductor device manufacturing -- the distances can't be made small enough and the error rate is just too high," says Liddle.


Story Source:

The above story is based on materials provided by National Institute of Standards and Technology (NIST). Note: Materials may be edited for content and length.


Journal References:

  1. Paul W. K. Rothemund. Folding DNA to create nanoscale shapes and patterns. Nature, 2006; 440 (7082): 297 DOI: 10.1038/nature04586
  2. Seung Hyeon Ko, Gregg M. Gallatin, J. Alexander Liddle. Nanomanufacturing with DNA Origami: Factors Affecting the Kinetics and Yield of Quantum Dot Binding. Advanced Functional Materials, 2012; 22 (5): 1015 DOI: 10.1002/adfm.201102077

Cite This Page:

National Institute of Standards and Technology (NIST). "Nanomanufacturing using DNA origami." ScienceDaily. ScienceDaily, 7 March 2012. <www.sciencedaily.com/releases/2012/03/120307112741.htm>.
National Institute of Standards and Technology (NIST). (2012, March 7). Nanomanufacturing using DNA origami. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2012/03/120307112741.htm
National Institute of Standards and Technology (NIST). "Nanomanufacturing using DNA origami." ScienceDaily. www.sciencedaily.com/releases/2012/03/120307112741.htm (accessed July 23, 2014).

Share This




More Matter & Energy News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Government Approves East Coast Oil Exploration

Government Approves East Coast Oil Exploration

AP (July 18, 2014) The Obama administration approved the use of sonic cannons to discover deposits under the ocean floor by shooting sound waves 100 times louder than a jet engine through waters shared by endangered whales and turtles. (July 18) Video provided by AP
Powered by NewsLook.com
Sunken German U-Boat Clearly Visible For First Time

Sunken German U-Boat Clearly Visible For First Time

Newsy (July 18, 2014) The wreckage of the German submarine U-166 has become clearly visible for the first time since it was discovered in 2001. Video provided by Newsy
Powered by NewsLook.com
Obama: U.S. Must Have "smartest Airports, Best Power Grid"

Obama: U.S. Must Have "smartest Airports, Best Power Grid"

Reuters - US Online Video (July 17, 2014) President Barak Obama stopped by at a lunch counter in Delaware before making remarks about boosting the nation's infrastructure. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Crude Oil Prices Bounce Back After Falling Below $100 a Barrel

Crude Oil Prices Bounce Back After Falling Below $100 a Barrel

TheStreet (July 16, 2014) Oil Futures are bouncing back after tumbling below $100 a barrel for the first time since May yesterday. Jeff Grossman is the president of BRG Brokerage and trades at the NYMEX. Grossman tells TheStreet the Middle East is always a concern for oil traders. Oil prices were pushed down in recent weeks on Libya increasing its production. Supply disruptions in Iraq fading also contributed to prices falling. News from China's economic front showing a growth for the second quarter also calmed fears on its slowdown. Jeff Grossman talks to TheStreet's Susannah Lee on this and more on the Energy Department's Energy Information Administration (EIA) report. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins