Featured Research

from universities, journals, and other organizations

Treating psoriasis to prevent heart attacks and strokes

Date:
March 16, 2012
Source:
Montreal Heart Institute
Summary:
A clinical study shows that a new treatment for psoriasis could be associated with a significant decrease in vascular inflammation, a major risk factor of cardiovascular disease.

A clinical study co‐led by the Montreal Heart Institute and Innovaderm Research Inc., which was presented March 19 at the annual meeting of the American Academy of Dermatology, shows that a new treatment for psoriasis could be associated with a significant decrease in vascular inflammation, a major risk factor of cardiovascular disease.

Related Articles


Psoriasis is a chronic inflammatory disease of the skin and joints that affects up to 3% of the population. This disease is associated with a greater risk of heart attack (infarction) and stroke. The goal of this clinical study was to show that a treatment to reduce skin inflammation in psoriasis patients could be associated with a decrease in vascular inflammation.

The study had positive results, as vascular inflammation decreased significantly in patients suffering from psoriasis who were treated with adalimumab, a biological anti‐inflammatory compound. The study also showed a 51% decrease in C‐reactive protein among patients treated with adalimumab compared to a 2% decrease among patients in the control group. These results are significant, as a high level of C‐reactive protein is known to be associated with an increased risk of heart attack and stroke. In relation to the treatment of psoriasis, 70% of patients who received the compound presented with a major decrease in skin lesion severity, compared to 20% of patients in the control group.

According to Dr. Robert Bissonnette, President and Founder of Innovaderm Research Inc. and co‐principal author of the study, who will present the findings at the annual meeting of the American Academy of Dermatology, "This study is a great example of the high‐level research being conducted in Montréal. "He added that this clinical research study suggests that it is possible to assess the impact of psoriasis treatments on the heart without having to resort to long‐term studies that require thousands of patients and have higher costs.

"These findings are extremely encouraging for people suffering from psoriasis, as they face a greater risk of cardiovascular disease," explained Dr. Jean‐Claude Tardif, Director of the Research Centre of the Montreal Heart Institute and co‐principal author of the study. He also emphasized the importance of regular medical follow‐up for people with psoriasis to prevent cardiovascular events and establish an optimum therapeutic approach.

Imaging as a vascular inflammation measurement tool

Between May 2009 and June 2011, 30 patients suffering from moderate to severe psoriasis and with a history of coronary artery disease or multiple associated risk factors were followed for four months as part of a randomized clinical study. The patients were divided into two groups: the first group was treated with sub‐cutaneous injections of adalimumab while the second group received no treatment or a routine treatment (i.e., topical formulation, phototherapy). Each patient's level of vascular inflammation was measured at the start and end of the study with positron emission tomography (PET), a type of medical imaging, to scan the carotid arteries and the ascending aorta.


Story Source:

The above story is based on materials provided by Montreal Heart Institute. Note: Materials may be edited for content and length.


Cite This Page:

Montreal Heart Institute. "Treating psoriasis to prevent heart attacks and strokes." ScienceDaily. ScienceDaily, 16 March 2012. <www.sciencedaily.com/releases/2012/03/120316101632.htm>.
Montreal Heart Institute. (2012, March 16). Treating psoriasis to prevent heart attacks and strokes. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2012/03/120316101632.htm
Montreal Heart Institute. "Treating psoriasis to prevent heart attacks and strokes." ScienceDaily. www.sciencedaily.com/releases/2012/03/120316101632.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins