Featured Research

from universities, journals, and other organizations

Nanopills release drugs directly from the inside of cells

Date:
March 16, 2012
Source:
Universitat Autonoma de Barcelona
Summary:
Researchers in Spain have created nanoparticles which can release drugs directly from the cells' interior. The technology, which has been named "nanopills," was licensed to a firm that has verified its tolerance by administering it in vivo.

Nanopills.
Credit: Image courtesy of Universitat Autonoma de Barcelona

Researchers at Universitat Autonoma de Barcelona (UAB) have created nanoparticles which could release drugs directly from the cells' interior. The technology, which has been named "nanopills," was licensed to the firm Janus Developments of the Barcelona Scientific Park, which verified its tolerance by administering it in vivo.

UAB researchers developed a new vehicle to release proteins with therapeutic effects. This is known as "bacteria-inclusion bodies," stable insoluble nanoparticles which normally are found in recombinant bacteria. Even though these inclusion bodies traditionally have been an obstacle in the industrial production of soluble enzymes and biodrugs, they were recently recognised as having large amounts of functional proteins with direct values in industrial and biomedical applications.

The research team led by Antoni Vallverde from the Institute of Biotechnology and Biomedicine (IBB) at UAB worked in collaboration with the Online Biomedical Research Centre for Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN) to verify the value of these nanoparticles as natural "nanopills" with a strong capacity to penetrate cells and carry out biological activities. The nanopill concept represents a new and promising platform for drug administration and illustrates the yet to be explored power of microbian materials in medicine.

The researchers, in a multidisciplinary study at UAB led by Dr Esther Vàzquez, packaged four proteins containing different therapeutic effects into experimental nanopills, the inclusion bodies of the bacteria Escherichia coli. They put the bacteria in contact with cell cultures of mammals under similar conditions to those found in real clinical pathologies, "sick" cells with low viability, and achieved to recover their activity.

Once the technology was licensed to Janus Developments, the tolerance of its administration in vivo were confirmed through experiments conducted by UAB researcher Ester Fernández. The results and detailed description of the "nanopill" were published this week in the journal Advanced Materials.

The multidisciplinary study included researchers from IBB, the UAB Departments of Genetics and Microbiology and of Cell Biology, Physiology and Immunology, the CIBER-BBN, the CIBER-EHD (Online Biomedical Research Centre for Hepatic and Digestive Diseases), the firm Janus Developments, the Leibniz University of Hannover and the Helmholtz Centre for Infection Research in Germany.

The use of inclusion bodies as therapeutic agents was patented by UAB and CIBER-BBN (patent code: WO2010131117A1), and licensed to the biotechnology firm Janus Developments, which currently invests in the development of the product.


Story Source:

The above story is based on materials provided by Universitat Autonoma de Barcelona. Note: Materials may be edited for content and length.


Journal Reference:

  1. Esther Vázquez, José L. Corchero, Joan F. Burgueño, Joaquin Seras-Franzoso, Ana Kosoy, Ramon Bosser, Rosa Mendoza, Joan Marc Martínez-Láinez, Ursula Rinas, Ester Fernández, Luis Ruiz-Avila, Elena García-Fruitós, Antonio Villaverde. Functional Inclusion Bodies Produced in Bacteria as Naturally Occurring Nanopills for Advanced Cell Therapies. Advanced Materials, 2012; DOI: 10.1002/adma.201104330

Cite This Page:

Universitat Autonoma de Barcelona. "Nanopills release drugs directly from the inside of cells." ScienceDaily. ScienceDaily, 16 March 2012. <www.sciencedaily.com/releases/2012/03/120316145755.htm>.
Universitat Autonoma de Barcelona. (2012, March 16). Nanopills release drugs directly from the inside of cells. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2012/03/120316145755.htm
Universitat Autonoma de Barcelona. "Nanopills release drugs directly from the inside of cells." ScienceDaily. www.sciencedaily.com/releases/2012/03/120316145755.htm (accessed July 22, 2014).

Share This




More Matter & Energy News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Government Approves East Coast Oil Exploration

Government Approves East Coast Oil Exploration

AP (July 18, 2014) — The Obama administration approved the use of sonic cannons to discover deposits under the ocean floor by shooting sound waves 100 times louder than a jet engine through waters shared by endangered whales and turtles. (July 18) Video provided by AP
Powered by NewsLook.com
Sunken German U-Boat Clearly Visible For First Time

Sunken German U-Boat Clearly Visible For First Time

Newsy (July 18, 2014) — The wreckage of the German submarine U-166 has become clearly visible for the first time since it was discovered in 2001. Video provided by Newsy
Powered by NewsLook.com
Obama: U.S. Must Have "smartest Airports, Best Power Grid"

Obama: U.S. Must Have "smartest Airports, Best Power Grid"

Reuters - US Online Video (July 17, 2014) — President Barak Obama stopped by at a lunch counter in Delaware before making remarks about boosting the nation's infrastructure. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Crude Oil Prices Bounce Back After Falling Below $100 a Barrel

Crude Oil Prices Bounce Back After Falling Below $100 a Barrel

TheStreet (July 16, 2014) — Oil Futures are bouncing back after tumbling below $100 a barrel for the first time since May yesterday. Jeff Grossman is the president of BRG Brokerage and trades at the NYMEX. Grossman tells TheStreet the Middle East is always a concern for oil traders. Oil prices were pushed down in recent weeks on Libya increasing its production. Supply disruptions in Iraq fading also contributed to prices falling. News from China's economic front showing a growth for the second quarter also calmed fears on its slowdown. Jeff Grossman talks to TheStreet's Susannah Lee on this and more on the Energy Department's Energy Information Administration (EIA) report. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins