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Researchers create cellular automation model to study complex tumor-host role in cancer

Date:
March 27, 2012
Source:
American Institute of Physics
Summary:
To better understand the role complex tumor-host interactions play in tumor growth, researchers have developed a cellular automation model for tumor growth in heterogeneous microenvironments.

Cancer remains a medical mystery -- despite all of the research efforts devoted to understanding and controlling it. The most sought-after tumor model is one that would be able to formulate theoretical and computational tools to predict cancer progression and propose individual treatment strategies.

To better understand the role complex tumor-host interactions play in tumor growth, Princeton University researchers developed a cellular automation model for tumor growth in heterogeneous microenvironments. They then used this same model to investigate the effects of pressure on the growth of a solid tumor in a confined heterogeneous environment, such as a brain cancer growing in the cranium, and discovered that pressure accumulated during tumor growth can lead to a wide spectrum of growth dynamics and morphologies for both noninvasive and invasive tumors.

Depending on the magnitude of the pressure and the physical properties of the host environment, the types of tumor patterns that emerge range from strongly malignant tumors characterized by finger-like protrusions at the tumor surface to those in which fingering growth is diminished.

These results should have important applications for cancer diagnosis, prognosis, and therapy.


Story Source:

The above story is based on materials provided by American Institute of Physics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yang Jiao, Salvatore Torquato. Diversity of dynamics and morphologies of invasive solid tumors. AIP Advances, 2012; 2 (1): 011003 DOI: 10.1063/1.3697959

Cite This Page:

American Institute of Physics. "Researchers create cellular automation model to study complex tumor-host role in cancer." ScienceDaily. ScienceDaily, 27 March 2012. <www.sciencedaily.com/releases/2012/03/120327152909.htm>.
American Institute of Physics. (2012, March 27). Researchers create cellular automation model to study complex tumor-host role in cancer. ScienceDaily. Retrieved July 21, 2014 from www.sciencedaily.com/releases/2012/03/120327152909.htm
American Institute of Physics. "Researchers create cellular automation model to study complex tumor-host role in cancer." ScienceDaily. www.sciencedaily.com/releases/2012/03/120327152909.htm (accessed July 21, 2014).

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