Featured Research

from universities, journals, and other organizations

'Resuscitating' antibiotics to overcome drug resistance

Date:
March 27, 2012
Source:
Society for General Microbiology
Summary:
Combining common antibiotics with additional compounds could make previously resistant bacteria more susceptible to the same antibiotics. 'Resuscitation' of existing antibiotics has the potential to make infections caused by multidrug-resistant bacteria easier to control, reducing antibiotic usage and levels of antimicrobial resistance, say scientists.

Combining common antibiotics with additional compounds could make previously resistant bacteria more susceptible to the same antibiotics. 'Resuscitation' of existing antibiotics has the potential to make infections caused by multidrug-resistant bacteria easier to control, reducing antibiotic usage and levels of antimicrobial resistance, say scientists who recently presented their work at the Society for General Microbiology's Spring Conference in Dublin.

Related Articles


Researchers from University College Dublin (UCD) studied a variety of bacteria that are frequently associated with hospital-acquired infections, including Pseudomonas, Klebsiella, Enterobacter and Staphylococcus. Bacterial samples were collected from hospital patients and from these, strains that showed resistance to a commonly prescribed antibiotic -- ciprofloxacin -- were selected for study.

The team tested ciprofloxacin in combination with one of five different 'adjuvant' compounds against these bacteria, to determine which combinations, if any, were more effective than treatment with ciprofloxacin alone. Results showed that all five adjuvant compounds increased the efficacy of ciprofloxacin; making it more active against the bacteria by up to six-fold. .

Dr Marta Martins, from the UCD School of Public Health, Physiotherapy and Population Science, who is leading the study explained why this adjuvant therapy approach is so important. "Antimicrobial resistance is a growing problem that is threatening to make many infections impossible to treat. There are very few new antibacterial drugs coming onto the market so it is vital that we find ways to extend the use of existing antibiotics as much as possible," she said. "Adjuvant therapy essentially means that antibiotics that are currently ineffective can be 'resuscitated' to treat infections that previously would have been considered resistant."

The team believes that adjuvant therapy could revolutionize the way that antibiotics are used nowadays. "Hopefully this work will allow antibiotics to be incorporated into treatment regimes and administered in more effective ways," said Dr Martins. "As well as extending the lifespan of current antibiotics, this approach could ultimately reduce levels of antimicrobial resistance in hospitals as well as in the community, allowing hard-to-treat bacterial infections to be successfully controlled," she said.


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "'Resuscitating' antibiotics to overcome drug resistance." ScienceDaily. ScienceDaily, 27 March 2012. <www.sciencedaily.com/releases/2012/03/120327215953.htm>.
Society for General Microbiology. (2012, March 27). 'Resuscitating' antibiotics to overcome drug resistance. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2012/03/120327215953.htm
Society for General Microbiology. "'Resuscitating' antibiotics to overcome drug resistance." ScienceDaily. www.sciencedaily.com/releases/2012/03/120327215953.htm (accessed October 25, 2014).

Share This



More Plants & Animals News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins