Featured Research

from universities, journals, and other organizations

New research could stop tumour cells from spreading

Date:
April 2, 2012
Source:
University of Gothenburg
Summary:
Researchers have managed for the first time to obtain detailed information about the role of the protein metastasin in the spread of tumor cells.

Researchers from the Department of Chemistry and Molecular Biology at the University of Gothenburg have managed for the first time to obtain detailed information about the role of the protein metastasin in the spread of tumour cells. Published recently in Proceedings of the National Academy of Sciences (PNAS), the study paves the way for the development of new drugs.

Related Articles


Metastasin is a protein with a key role in the spread of tumour cells.

Previous research has shown that it is activated through the binding of calcium ions and then binds to and modulates other proteins.

Increases the spread of tumour cells

One of metastasin's binding partners is a motor protein called non-muscle myosin. Motor proteins are the driving force behind cell mobility. By binding to this protein, metastasin can increase the spread of tumour cells, acting as a kind of gas pedal for the cancer engine.

"Using a method called X-ray crystallography, we have managed for the first time to obtain detailed information on how metastasin binds to a motor protein, a process that facilitates the spread of tumour cells," explains researcher Gergely Katona.

Detailed picture

It has been possible to image metastasin and calcium-ion-bound metastasin using X-ray crystallography before, but the researchers at the University of Gothenburg are the first to have imaged the structure of calcium-ion-activated metastasin with an attached non-muscle myosin fragment.

"This has given us information about regions of both metastasin and the motor protein that are crucial for metastasin's ability to bind to the motor protein. This is important to know for drugs to be developed that block these specific regions and so prevent this binding."

The image of the two molecules gives us a better understanding of how metastasin binds to the motor protein, so increasing cell mobility and the spread of tumour cells. This understanding in turn paves the way for the development of new drugs to prevent this harmful interaction between molecules and so stop tumour cells from spreading.

"The metastasin and the motor protein can be imaged as a snapshot, but the next stage is to create a kind of video to see how the molecules move when binding to one another," explains Katona.

Gergely Katona is a researcher at the Department of Chemistry and Molecular Biology at the University of Gothenburg.


Story Source:

The above story is based on materials provided by University of Gothenburg. The original article was written by Carina Eliasson. Note: Materials may be edited for content and length.


Journal Reference:

  1. B. Kiss, A. Duelli, L. Radnai, K. A. Kekesi, G. Katona, L. Nyitray. Crystal structure of the S100A4-nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1114732109

Cite This Page:

University of Gothenburg. "New research could stop tumour cells from spreading." ScienceDaily. ScienceDaily, 2 April 2012. <www.sciencedaily.com/releases/2012/04/120402124233.htm>.
University of Gothenburg. (2012, April 2). New research could stop tumour cells from spreading. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2012/04/120402124233.htm
University of Gothenburg. "New research could stop tumour cells from spreading." ScienceDaily. www.sciencedaily.com/releases/2012/04/120402124233.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins