Featured Research

from universities, journals, and other organizations

A new 'Achilles' heel' in fungus that causes dandruff

Date:
April 25, 2012
Source:
American Chemical Society
Summary:
Research on the fungus that ranks as one cause of dandruff -- the embarrassing nuisance that, by some accounts, afflicts half of humanity -- is pointing scientists toward a much-needed new treatment for the condition's flaking and itching.

Research on the fungus that ranks as one cause of dandruff -- the embarrassing nuisance that, by some accounts, afflicts half of humanity -- is pointing scientists toward a much-needed new treatment for the condition's flaking and itching.
Credit: zollster / Fotolia

Research on the fungus that ranks as one cause of dandruff -- the embarrassing nuisance that, by some accounts, afflicts half of humanity -- is pointing scientists toward a much-needed new treatment for the condition's flaking and itching.

The advance is the topic of a report in ACS' Journal of Medicinal Chemistry.

Claudiu T. Supuran and colleagues explain that dandruff involves an excessive shedding of dead skin cells from the scalp. In people without dandruff, it takes about 30 days for a crop of new skin cells to mature, die and shed. In people with dandruff, it may take only 2-7 days. Irritation by the scalp-dwelling fungus Malassezia globosa (M. globosa) is one cause of dandruff. Shampoos and other dandruff treatments contain anti-fungal agents, but the authors say new medicines are badly needed since the two existing compounds are not very effective at preventing and treating dandruff.

In the quest for a better treatment, Supuran's group identified an enzyme in M. globosa that is essential for the fungus's growth. Tests showed that sulfonamides, a family of existing antibiotic medicines, were more effective in preventing the fungus's growth than ketoconazole, a widely used anti-fungal medicine that is an ingredient in certain dandruff treatments. As a result of the study, the scientists believe that the enzyme is a prime target for developing better anti-dandruff medicines.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kirsty S. Hewitson, Daniela Vullo, Andrea Scozzafava, Antonio Mastrolorenzo, Claudiu T. Supuran. Molecular Cloning, Characterization, and Inhibition Studies of a β-Carbonic Anhydrase fromMalassezia globosa, a Potential Antidandruff Target. Journal of Medicinal Chemistry, 2012; 55 (7): 3513 DOI: 10.1021/jm300203r

Cite This Page:

American Chemical Society. "A new 'Achilles' heel' in fungus that causes dandruff." ScienceDaily. ScienceDaily, 25 April 2012. <www.sciencedaily.com/releases/2012/04/120425140405.htm>.
American Chemical Society. (2012, April 25). A new 'Achilles' heel' in fungus that causes dandruff. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2012/04/120425140405.htm
American Chemical Society. "A new 'Achilles' heel' in fungus that causes dandruff." ScienceDaily. www.sciencedaily.com/releases/2012/04/120425140405.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins