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Allergies: Gut flora affects maturation of B cells in infants

Date:
May 7, 2012
Source:
University of Gothenburg
Summary:
Infants whose gut is colonised by E. coli bacteria early in life have a higher number of memory B cells in their blood, reveals a new study of infants.
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Infants whose gut is colonized by E. coli bacteria early in life have a higher number of memory B cells in their blood, reveals a study of infants carried out at the Sahlgrenska Academy at the University of Gothenburg, Sweden.

The bacteria in our gut outnumber the cells in our bodies by a factor of ten and are extremely important for our health because they stimulate the maturation of the immune system. The normal bacterial flora in the gut is established at the very beginning of our lives, but an increasingly hygienic lifestyle has led to changes in this flora.

Colonised ever later

These days Swedish children are colonized by E. coli bacteria later and later. They also have a less varied bacterial flora and a smaller turnover of bacterial strains in the gut than children in developing countries. Meanwhile, diseases caused by deficiencies in immune regulation have increased sharply, making allergies a major public health issue in the Western World.

B cells play key role in development of allergies

Researchers at the University of Gothenburg's Sahlgrenska Academy have looked at B cells, a type of white blood cell that produces antibodies that can protect the body against infection and play a key role in the development of allergies. By studying 65 healthy newborn babies in the Västra Götaland region, researcher Anna-Carin Lundell and her colleagues were able to show that infants whose gut is colonized by E. coli bacteria during the first few weeks of life had a higher number of memory B cells at the age of both four and 18 months.

"The results are important for understanding the relationship between our complex bacterial gut flora and our immune system, and show what we risk losing with an excessively hygienic lifestyle," Anna-Carin Lundell explains.

"Most of the bacteria around us are harmless, and we should see them as a very important form of training so that our children's immune systems mature properly. Healthy newborns should not be over-protected against natural exposure of the gut flora."


Story Source:

The above post is reprinted from materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. A.-C. Lundell, V. Bjornsson, A. Ljung, M. Ceder, S. Johansen, G. Lindhagen, C.-J. Tornhage, I. Adlerberth, A. E. Wold, A. Rudin. Infant B Cell Memory Differentiation and Early Gut Bacterial Colonization. The Journal of Immunology, 2012; 188 (9): 4315 DOI: 10.4049/jimmunol.1103223

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University of Gothenburg. "Allergies: Gut flora affects maturation of B cells in infants." ScienceDaily. ScienceDaily, 7 May 2012. <www.sciencedaily.com/releases/2012/05/120507141146.htm>.
University of Gothenburg. (2012, May 7). Allergies: Gut flora affects maturation of B cells in infants. ScienceDaily. Retrieved September 5, 2015 from www.sciencedaily.com/releases/2012/05/120507141146.htm
University of Gothenburg. "Allergies: Gut flora affects maturation of B cells in infants." ScienceDaily. www.sciencedaily.com/releases/2012/05/120507141146.htm (accessed September 5, 2015).

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